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Papers Benchmarks Datasets Tasks

Protein property prediction research benchmarks · SOTA2 Research

Protein property prediction

Benchmarks

Dataset NameSOTA MethodSort

Dataset NameSOTA methodMetricTrendResultsLast Updated

21 protein property datasets 48 data points (Cross-validation)

6.65Spearman Correlation

40

Jun 11, 2026

21 protein landscapes Unseen mutations 96 data points

7.1Spearman Correlation

31

Jun 11, 2026

21 protein landscapes Extrapolation 512 training points

0.759Spearman Correlation

22

Jun 11, 2026

21 protein landscapes 128 training points (extrapolation)

0.669Spearman Correlation

22

Jun 11, 2026

21 protein landscapes 1536 train points (cross-val)

0.867Spearman Correlation

22

Jun 11, 2026

21 protein property datasets 512 data points (Extrapolation)

7.24Spearman Correlation

18

Jun 11, 2026

21 protein property datasets 128 data points (Extrapolation)

6.81Spearman Correlation

18

Jun 11, 2026

Protein Property Prediction multi-task experiment 700 training points (test)

CLOCK-GP+CNN-ZS

0.911Spearman Correlation

14

Jun 11, 2026

Protein Property Prediction multi-task experiment 150 train points (test)

CLOCK-GP+CNN-ZS

0.852Spearman Correlation

14

Jun 11, 2026

Protein Property Prediction multi-task experiment 50 training points (test)

CLOCK-GP+CNN-ZS

0.8Spearman Corr

14

Jun 11, 2026

69Antibiotic Resistance Accuracy

13

Apr 28, 2026

21 protein landscapes (val)

7.48Spearman Correlation

9

Jun 11, 2026

Protein Property Datasets (Unseen mutations)

0.629Spearman Correlation

9

Jun 11, 2026

21 protein property datasets (Cross-validation)

0.867Spearman Correlation

9

Jun 11, 2026

15-task protein benchmark suite (test)

Masked-pos ESM2-150M (Run 2)

74.21Macro Mean Score

9

May 11, 2026

GB1 Hamming distance cutoff D = 2 (Extrapolation)

MLP-ESM2-LastLayer

0.44Spearman Correlation

6

Jun 11, 2026

GB1 (Cross-validation)

MLP-ESM2-LastLayer

0.53Spearman R

6

Jun 11, 2026

21 Protein Property Landscapes 512 (Extrapolation train)

1.26NLL

5

Jun 11, 2026

21 Protein Property Landscapes 128 training data points (Extrapolation)

1.95NLL

5

Jun 11, 2026

21 Protein Property Landscapes 96 train (Unseen mutations)

2.56NLL

5

Jun 11, 2026

21 Protein Property Landscapes 1536 (train val)

0.112NLL

5

Jun 11, 2026

21 Protein Property Landscapes 48 (train Cross-val)

0.987NLL

5

Jun 11, 2026

TAPE (downstream)

0.23Remote Homology

4

Feb 26, 2026

beta-lactamase-PEER (test)

Masked-pos MLM+JEPA

4Win/Loss/Tie Counts

1

May 11, 2026

Popular datasets

protein landscapes Protein Property Landscapes protein property datasets Protein Property Prediction GB1

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