Protein Property Prediction on 21 protein landscapes 1536 train points (cross-val) benchmark leaderboard · SOTA2 Research

Protein Property Prediction on 21 protein landscapes 1536 train points (cross-val)

0.867Spearman CorrelationLOCK-GP

Evaluation Results

Method	Links
LOCK-GP2026.06		0.867	0.914	0.21
ConFit2026.06		0.863	0.867	0.344
MLP-ESM2-8M2026.06		0.856	0.898	0.256
MLP-ESM2-LastLayer2026.06		0.851	0.9	0.243
MLP-SaProt-LastLayer2026.06		0.851	0.903	0.238
Kermut-GP2026.06		0.85	0.888	0.285
Tanimoto-GP2026.06		0.846	0.888	0.272
MLP-ESM2-8M-RandInit2026.06		0.839	0.88	0.295
Ridge-ESM2-8M2026.06		0.837	0.877	0.301
Ridge-ESM2-650M2026.06		0.836	0.877	0.304
MLP-ESM2-650M2026.06		0.828	0.873	0.288
KermutStruc-GP2026.06		0.809	0.805	0.417
Ridge-OH-ESM2-650M-Aug2026.06		0.804	0.805	0.419
SigGLM-OH2026.06		0.804	0.849	0.342
Ridge-OH2026.06		0.802	0.8	0.422
MLP-ESM2-8M-MeanPool2026.06		0.797	0.843	0.362
KermutSeq-GP2026.06		0.794	0.838	0.338
Ridge-ESM2-8M-MeanPool2026.06		0.786	0.829	0.376
MLP-OH-ESM2-650M-Aug2026.06		0.771	0.818	0.442
MLP-OH2026.06		0.764	0.808	0.459
BLOSUM50-ZeroShot2026.06		0.396	0.386	—
ESM2-650M-ZeroShot2026.06		-0.044	-0.04	—