Protein Property Prediction on 21 protein landscapes Extrapolation 512 training points
0.759Spearman CorrelationLOCK-GP
Evaluation Results
| Method | Links | |||
|---|---|---|---|---|
| LOCK-GP2026.06 | 0.759 | 0.807 | 0.439 | |
| MLP-SaProt-LastLayerBackbone=SaProt, Pooling=LastLayer2026.06 | 0.751 | 0.759 | 0.609 | |
| Kermut-GP2026.06 | 0.75 | 0.767 | 0.67 | |
| Tanimoto-GP2026.06 | 0.739 | 0.769 | 0.574 | |
| MLP-ESM2-8MBackbone=ESM2-8M2026.06 | 0.739 | 0.763 | 0.562 | |
| MLP-ESM2-LastLayerBackbone=ESM2, Pooling=LastLayer2026.06 | 0.738 | 0.742 | 0.618 | |
| ConFit2026.06 | 0.733 | 0.723 | 0.828 | |
| Ridge-ESM2-8MBackbone=ESM2-8M, Classifier=Ridge2026.06 | 0.719 | 0.74 | 0.685 | |
| Ridge-ESM2-650MBackbone=ESM2-650M, Classifier=Ridge2026.06 | 0.71 | 0.729 | 0.685 | |
| MLP-ESM2-8M-RandInitBackbone=ESM2-8M, Initialization=Random2026.06 | 0.709 | 0.727 | 0.606 | |
| KermutStruc-GP2026.06 | 0.706 | 0.713 | 0.847 | |
| Ridge-OH-ESM2-650M-AugFeatures=One-Hot + ESM2-650M-Aug, Classifier=Ridge2026.06 | 0.703 | 0.705 | 0.864 | |
| SigGLM-OHBackbone=One-Hot2026.06 | 0.697 | 0.724 | 0.669 | |
| Ridge-OHBackbone=One-Hot, Classifier=Ridge2026.06 | 0.694 | 0.698 | 0.877 | |
| MLP-OH-ESM2-650M-AugFeatures=One-Hot + ESM2-650M-Aug2026.06 | 0.681 | 0.702 | 0.737 | |
| MLP-ESM2-650MBackbone=ESM2-650M2026.06 | 0.677 | 0.702 | 0.64 | |
| MLP-ESM2-8M-MeanPoolBackbone=ESM2-8M, Pooling=MeanPool2026.06 | 0.658 | 0.673 | 0.679 | |
| Ridge-ESM2-8M-MeanPoolBackbone=ESM2-8M, Pooling=MeanPool, Classifier=Ridge2026.06 | 0.654 | 0.658 | 0.762 | |
| MLP-OHBackbone=One-Hot2026.06 | 0.653 | 0.68 | 0.81 | |
| KermutSeq-GP2026.06 | 0.605 | 0.614 | 0.714 | |
| BLOSUM50-ZeroShotMode=ZeroShot2026.06 | 0.27 | 0.256 | — | |
| ESM2-650M-ZeroShotMode=ZeroShot2026.06 | -0.072 | -0.063 | — |