Protein Property Prediction on 21 protein landscapes 128 training points (extrapolation)
0.669Spearman CorrelationLOCK-GP
Evaluation results
| Method | Links | |||
|---|---|---|---|---|
| LOCK-GP2026.06 | 0.669 | 0.711 | 0.592 | |
| MLP-SaProt-LastLayerBackbone=SaProt, Pooling=LastLayer2026.06 | 0.644 | 0.64 | 0.789 | |
| Kermut-GP2026.06 | 0.639 | 0.654 | 0.845 | |
| Tanimoto-GP2026.06 | 0.632 | 0.654 | 0.762 | |
| ConFit2026.06 | 0.632 | 0.622 | 0.882 | |
| Ridge-ESM2-8MBackbone=ESM2-8M, Classifier=Ridge2026.06 | 0.629 | 0.653 | 0.781 | |
| MLP-ESM2-LastLayerBackbone=ESM2, Pooling=LastLayer2026.06 | 0.628 | 0.619 | 0.771 | |
| KermutStruc-GP2026.06 | 0.624 | 0.641 | 0.847 | |
| Ridge-ESM2-650MBackbone=ESM2-650M, Classifier=Ridge2026.06 | 0.623 | 0.649 | 0.864 | |
| MLP-ESM2-8MBackbone=ESM2-8M2026.06 | 0.621 | 0.648 | 0.711 | |
| Ridge-OH-ESM2-650M-AugFeatures=One-Hot + ESM2-650M-Aug, Classifier=Ridge2026.06 | 0.62 | 0.624 | 0.909 | |
| MLP-OH-ESM2-650M-AugFeatures=One-Hot + ESM2-650M-Aug2026.06 | 0.619 | 0.632 | 0.789 | |
| Ridge-OHBackbone=One-Hot, Classifier=Ridge2026.06 | 0.589 | 0.599 | 0.939 | |
| SigGLM-OHBackbone=One-Hot2026.06 | 0.587 | 0.61 | 0.8 | |
| MLP-ESM2-8M-RandInitBackbone=ESM2-8M, Initialization=Random2026.06 | 0.581 | 0.609 | 0.747 | |
| MLP-OHBackbone=One-Hot2026.06 | 0.577 | 0.596 | 0.863 | |
| MLP-ESM2-650MBackbone=ESM2-650M2026.06 | 0.568 | 0.576 | 0.767 | |
| Ridge-ESM2-8M-MeanPoolBackbone=ESM2-8M, Pooling=MeanPool, Classifier=Ridge2026.06 | 0.552 | 0.564 | 0.886 | |
| MLP-ESM2-8M-MeanPoolBackbone=ESM2-8M, Pooling=MeanPool2026.06 | 0.536 | 0.553 | 0.814 | |
| KermutSeq-GP2026.06 | 0.518 | 0.505 | 0.836 | |
| BLOSUM50-ZeroShotMode=ZeroShot2026.06 | 0.27 | 0.256 | — | |
| ESM2-650M-ZeroShotMode=ZeroShot2026.06 | -0.072 | -0.063 | — |