Protein Property Prediction on 21 protein landscapes Unseen mutations 96 data points benchmark leaderboard · SOTA2 Research

Protein Property Prediction on 21 protein landscapes Unseen mutations 96 data points

7.1Spearman CorrelationRidge-OH

Evaluation Results

Method	Links
Ridge-OH2026.06		7.1	7.38	6.71
SigGLM-OH2026.06		6.48	5.9	5.71
KermutSeq-GP2026.06		6.05	6	5.38
Ridge-ESM22026.06		5.9	6.05	6.57
Tanimoto-GP2026.06		4.9	4.71	5.9
MLP-ESM2-LastLayer2026.06		4.48	4.52	4.05
KermutStruc-GP2026.06		3.57	4.05	4.38
Kermut-GP2026.06		3.29	3.43	3.48
LOCK-GP2026.06		3.24	2.95	2.81
Kermut-GP2026.06		0.629	0.632	0.617
KermutStruc-GP2026.06		0.614	0.613	0.634
LOCK-GP2026.06		0.61	0.622	0.591
MLP-SaProt-LastLayer2026.06		0.568	0.583	0.633
MLP-OH-ESM2-650M-Aug2026.06		0.567	0.589	0.62
MLP-ESM2-LastLayer2026.06		0.558	0.573	0.626
Tanimoto-GP2026.06		0.555	0.56	0.675
Ridge-OH-ESM2-650M-Aug2026.06		0.549	0.552	0.716
ConFit2026.06		0.548	0.545	0.726
KermutSeq-GP2026.06		0.532	0.537	0.681
MLP-ESM2-8M2026.06		0.53	0.551	0.678
SigGLM-OH2026.06		0.515	0.535	0.661
Ridge-OH2026.06		0.514	0.519	0.682
MLP-OH2026.06		0.506	0.527	0.668
Ridge-ESM2-650M2026.06		0.506	0.523	1.007
MLP-ESM2-8M-MeanPool2026.06		0.501	0.51	0.725
MLP-ESM2-650M2026.06		0.496	0.511	0.76
MLP-ESM2-8M-RandInit2026.06		0.496	0.517	0.705
Ridge-ESM2-8M2026.06		0.476	0.49	1.628
Ridge-ESM2-8M-MeanPool2026.06		0.361	0.37	1.617
BLOSUM50-ZeroShot2026.06		0.291	0.281	—
ESM2-650M-ZeroShot2026.06		-0.07	-0.062	—