Protein Property Prediction on 21 protein landscapes Unseen mutations 96 data points
7.1Spearman CorrelationRidge-OH
Evaluation results
| Method | Links | |||
|---|---|---|---|---|
| Ridge-OHRepresentation=One-Hot2026.06 | 7.1 | 7.38 | 6.71 | |
| SigGLM-OHRepresentation=One-Hot2026.06 | 6.48 | 5.9 | 5.71 | |
| KermutSeq-GPtype=Sequence2026.06 | 6.05 | 6 | 5.38 | |
| Ridge-ESM2Backbone=ESM22026.06 | 5.9 | 6.05 | 6.57 | |
| Tanimoto-GP2026.06 | 4.9 | 4.71 | 5.9 | |
| MLP-ESM2-LastLayerBackbone=ESM2, Layer=LastLayer2026.06 | 4.48 | 4.52 | 4.05 | |
| KermutStruc-GPtype=Structure2026.06 | 3.57 | 4.05 | 4.38 | |
| Kermut-GP2026.06 | 3.29 | 3.43 | 3.48 | |
| LOCK-GP2026.06 | 3.24 | 2.95 | 2.81 | |
| Kermut-GP2026.06 | 0.629 | 0.632 | 0.617 | |
| KermutStruc-GP2026.06 | 0.614 | 0.613 | 0.634 | |
| LOCK-GP2026.06 | 0.61 | 0.622 | 0.591 | |
| MLP-SaProt-LastLayerBackbone=SaProt, Pooling=LastLayer2026.06 | 0.568 | 0.583 | 0.633 | |
| MLP-OH-ESM2-650M-AugFeatures=One-Hot + ESM2-650M-Aug2026.06 | 0.567 | 0.589 | 0.62 | |
| MLP-ESM2-LastLayerBackbone=ESM2, Pooling=LastLayer2026.06 | 0.558 | 0.573 | 0.626 | |
| Tanimoto-GP2026.06 | 0.555 | 0.56 | 0.675 | |
| Ridge-OH-ESM2-650M-AugFeatures=One-Hot + ESM2-650M-Aug, Classifier=Ridge2026.06 | 0.549 | 0.552 | 0.716 | |
| ConFit2026.06 | 0.548 | 0.545 | 0.726 | |
| KermutSeq-GP2026.06 | 0.532 | 0.537 | 0.681 | |
| MLP-ESM2-8MBackbone=ESM2-8M2026.06 | 0.53 | 0.551 | 0.678 | |
| SigGLM-OHBackbone=One-Hot2026.06 | 0.515 | 0.535 | 0.661 | |
| Ridge-OHBackbone=One-Hot, Classifier=Ridge2026.06 | 0.514 | 0.519 | 0.682 | |
| MLP-OHBackbone=One-Hot2026.06 | 0.506 | 0.527 | 0.668 | |
| Ridge-ESM2-650MBackbone=ESM2-650M, Classifier=Ridge2026.06 | 0.506 | 0.523 | 1.007 | |
| MLP-ESM2-8M-MeanPoolBackbone=ESM2-8M, Pooling=MeanPool2026.06 | 0.501 | 0.51 | 0.725 | |
| MLP-ESM2-650MBackbone=ESM2-650M2026.06 | 0.496 | 0.511 | 0.76 | |
| MLP-ESM2-8M-RandInitBackbone=ESM2-8M, Initialization=Random2026.06 | 0.496 | 0.517 | 0.705 | |
| Ridge-ESM2-8MBackbone=ESM2-8M, Classifier=Ridge2026.06 | 0.476 | 0.49 | 1.628 | |
| Ridge-ESM2-8M-MeanPoolBackbone=ESM2-8M, Pooling=MeanPool, Classifier=Ridge2026.06 | 0.361 | 0.37 | 1.617 | |
| BLOSUM50-ZeroShotMode=ZeroShot2026.06 | 0.291 | 0.281 | — | |
| ESM2-650M-ZeroShotMode=ZeroShot2026.06 | -0.07 | -0.062 | — |