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Protein Sequence Design research benchmarks · SOTA2 Research

Protein Sequence Design

Benchmarks

Dataset NameSOTA MethodSort

Dataset NameSOTA methodMetricTrendResultsLast Updated

RFDiffusion de novo backbones

1.78RMSD

19

Apr 21, 2026

CATH 4.3 (test)

3.97RMSD

18

Mar 10, 2026

CATH 4.3 (150-300 residues)

ProteinZeroGRPO

87.18TM Score

17

Mar 4, 2026

CATH 0-150 residues 4.3

ProteinZeroGRPO

87.98TM Score

17

Mar 4, 2026

Knowledge-Design

69.19Recovery

14

Feb 26, 2026

Knowledge-Design

62.79Recovery

14

Feb 26, 2026

CreiLOV fluorescence

102.75Coverage

4

Jun 9, 2026

Protein Sequences

102.75Coverage

4

Jun 9, 2026

PDB 394 proteins

8.9Success Rate (2)

2

Apr 21, 2026

Popular datasets

CATH TS50 TS500 PDB Protein Sequences

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