Protein Sequence Design on CATH 0-150 residues 4.3
87.98TM ScoreProteinZeroGRPO
Evaluation results
| Method | Links | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ProteinZeroGRPOOracle=AF32025.06 | 87.98 | — | — | — | 84.09 | — | 1.3406 | 94.67 | 91.56 | |
| ProteinZeroGRPOOracle=ESMFold2025.06 | 86.74 | — | — | — | 82.33 | — | 1.3727 | 93.55 | 90.13 | |
| ProteinZeroGRPO2025.06 | 86.7 | 59 | 22.616 | 24.924 | 82.326 | 30.6 | 1.373 | 93.55 | 90.13 | |
| ProteinZeroRAFTOracle=AF32025.06 | 86.12 | — | — | — | 83.48 | — | 1.3587 | 93.89 | 90.42 | |
| ProteinZeroRAFTOracle=ESMFold2025.06 | 84.94 | — | — | — | 81.56 | — | 1.3929 | 92.86 | 89.29 | |
| ProteinZeroRAFT2025.06 | 84.9 | 58.7 | 22.236 | 23.168 | 81.56 | 29.6 | 1.393 | 92.86 | 89.29 | |
| Multi-Round DPOOracle=AF32025.06 | 84.36 | — | — | — | 83.07 | — | 1.4176 | 89.95 | 88.71 | |
| DPOOracle=AF32025.06 | 84.01 | — | — | — | 82.93 | — | 1.4218 | 89.43 | 88.12 | |
| InstructPLMOracle=AF32025.06 | 83.56 | — | — | — | 82.45 | — | 1.4287 | 88.32 | 86.98 | |
| Multi-Round DPO2025.06 | 82.3 | 56.9 | 21.797 | 21.423 | 80.797 | 26.6 | 1.468 | 87.95 | 86.89 | |
| Multi-Round DPOOracle=ESMFold2025.06 | 82.28 | — | — | — | 80.8 | — | 1.4678 | 87.95 | 86.89 | |
| DPO2025.06 | 82 | 57.1 | 21.713 | 21.191 | 80.716 | 27.4 | 1.473 | 87.58 | 86.44 | |
| DPOOracle=ESMFold2025.06 | 81.98 | — | — | — | 80.72 | — | 1.4727 | 87.58 | 86.44 | |
| InstructPLMOracle=ESMFold2025.06 | 81.21 | — | — | — | 79.98 | — | 1.4842 | 85.71 | 84.45 | |
| InstructPLM2025.06 | 81.2 | 57.4 | 21.543 | 20.878 | 79.983 | 28.1 | 1.484 | 85.71 | 84.45 | |
| ProteinMPNN2025.06 | 80.5 | 42.6 | 21.509 | 20.792 | 79.883 | 28 | 1.5 | 82.14 | 81.95 | |
| ESM-IF2025.06 | 80.2 | 37.7 | 17.9 | 14.328 | 78.918 | 26.3 | 1.515 | 81.25 | 80.71 |