Protein Sequence Design on CATH 0-150 residues 4.3 benchmark leaderboard · SOTA2 Research

Protein Sequence Design on CATH 0-150 residues 4.3

87.98TM ScoreProteinZeroGRPO

Evaluation Results

Method	Links
ProteinZeroGRPO2025.06		87.98	—	—	—	84.09	—	1.3406	94.67	91.56
ProteinZeroGRPO2025.06		86.74	—	—	—	82.33	—	1.3727	93.55	90.13
ProteinZeroGRPO2025.06		86.7	59	22.616	24.924	82.326	30.6	1.373	93.55	90.13
ProteinZeroRAFT2025.06		86.12	—	—	—	83.48	—	1.3587	93.89	90.42
ProteinZeroRAFT2025.06		84.94	—	—	—	81.56	—	1.3929	92.86	89.29
ProteinZeroRAFT2025.06		84.9	58.7	22.236	23.168	81.56	29.6	1.393	92.86	89.29
Multi-Round DPO2025.06		84.36	—	—	—	83.07	—	1.4176	89.95	88.71
DPO2025.06		84.01	—	—	—	82.93	—	1.4218	89.43	88.12
InstructPLM2025.06		83.56	—	—	—	82.45	—	1.4287	88.32	86.98
Multi-Round DPO2025.06		82.3	56.9	21.797	21.423	80.797	26.6	1.468	87.95	86.89
Multi-Round DPO2025.06		82.28	—	—	—	80.8	—	1.4678	87.95	86.89
DPO2025.06		82	57.1	21.713	21.191	80.716	27.4	1.473	87.58	86.44
DPO2025.06		81.98	—	—	—	80.72	—	1.4727	87.58	86.44
InstructPLM2025.06		81.21	—	—	—	79.98	—	1.4842	85.71	84.45
InstructPLM2025.06		81.2	57.4	21.543	20.878	79.983	28.1	1.484	85.71	84.45
ProteinMPNN2025.06		80.5	42.6	21.509	20.792	79.883	28	1.5	82.14	81.95
ESM-IF2025.06		80.2	37.7	17.9	14.328	78.918	26.3	1.515	81.25	80.71