Protein Sequence Design on CATH 4.3 (150-300 residues) benchmark leaderboard · SOTA2 Research

Protein Sequence Design on CATH 4.3 (150-300 residues)

87.18TM ScoreProteinZeroGRPO

Evaluation Results

Method	Links
ProteinZeroGRPO2025.06		87.18	—	—	—	86.19	—	1.3598	91.76	92.27
ProteinZeroGRPO2025.06		86.2	58	40.626	32.805	84.154	33.1	1.393	90.43	91.19
ProteinZeroGRPO2025.06		86.17	—	—	—	84.15	—	1.3925	90.43	91.19
ProteinZeroRAFT2025.06		85.48	—	—	—	86.03	—	1.3891	90.72	90.64
Multi-Round DPO2025.06		84.67	—	—	—	85.94	—	1.3953	90.67	89.56
DPO2025.06		84.54	—	—	—	85.92	—	1.3978	90.58	89.31
InstructPLM2025.06		84.18	—	—	—	85.86	—	1.4018	90.12	88.41
ProteinZeroRAFT2025.06		84.13	—	—	—	83.85	—	1.4271	89.17	89.36
ProteinZeroRAFT2025.06		84.1	57.8	37.575	30.755	83.85	32.4	1.427	89.17	89.36
Multi-Round DPO2025.06		83.13	—	—	—	83.84	—	1.4372	89.04	88.05
Multi-Round DPO2025.06		83.1	56.9	36.483	29.087	83.84	28.8	1.437	89.04	88.05
DPO2025.06		83	57	36.417	28.915	83.837	29.6	1.441	88.97	87.7
DPO2025.06		82.96	—	—	—	83.84	—	1.4407	88.97	87.7
InstructPLM2025.06		82.41	—	—	—	83.78	—	1.4476	88.24	86.38
InstructPLM2025.06		82.4	57	36.362	27.145	83.783	30.5	1.448	88.24	86.38
ProteinMPNN2025.06		81.6	40.5	35.778	27.057	82.361	29.7	1.469	86.64	84.67
ESM-IF2025.06		80.2	44.6	32.125	24.816	82.042	27.9	1.487	86.09	82.81