Protein Sequence Design on CATH 4.3 (150-300 residues)
87.18TM ScoreProteinZeroGRPO
Evaluation results
| Method | Links | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ProteinZeroGRPOOracle=AF32025.06 | 87.18 | — | — | — | 86.19 | — | 1.3598 | 91.76 | 92.27 | |
| ProteinZeroGRPO2025.06 | 86.2 | 58 | 40.626 | 32.805 | 84.154 | 33.1 | 1.393 | 90.43 | 91.19 | |
| ProteinZeroGRPOOracle=ESMFold2025.06 | 86.17 | — | — | — | 84.15 | — | 1.3925 | 90.43 | 91.19 | |
| ProteinZeroRAFTOracle=AF32025.06 | 85.48 | — | — | — | 86.03 | — | 1.3891 | 90.72 | 90.64 | |
| Multi-Round DPOOracle=AF32025.06 | 84.67 | — | — | — | 85.94 | — | 1.3953 | 90.67 | 89.56 | |
| DPOOracle=AF32025.06 | 84.54 | — | — | — | 85.92 | — | 1.3978 | 90.58 | 89.31 | |
| InstructPLMOracle=AF32025.06 | 84.18 | — | — | — | 85.86 | — | 1.4018 | 90.12 | 88.41 | |
| ProteinZeroRAFTOracle=ESMFold2025.06 | 84.13 | — | — | — | 83.85 | — | 1.4271 | 89.17 | 89.36 | |
| ProteinZeroRAFT2025.06 | 84.1 | 57.8 | 37.575 | 30.755 | 83.85 | 32.4 | 1.427 | 89.17 | 89.36 | |
| Multi-Round DPOOracle=ESMFold2025.06 | 83.13 | — | — | — | 83.84 | — | 1.4372 | 89.04 | 88.05 | |
| Multi-Round DPO2025.06 | 83.1 | 56.9 | 36.483 | 29.087 | 83.84 | 28.8 | 1.437 | 89.04 | 88.05 | |
| DPO2025.06 | 83 | 57 | 36.417 | 28.915 | 83.837 | 29.6 | 1.441 | 88.97 | 87.7 | |
| DPOOracle=ESMFold2025.06 | 82.96 | — | — | — | 83.84 | — | 1.4407 | 88.97 | 87.7 | |
| InstructPLMOracle=ESMFold2025.06 | 82.41 | — | — | — | 83.78 | — | 1.4476 | 88.24 | 86.38 | |
| InstructPLM2025.06 | 82.4 | 57 | 36.362 | 27.145 | 83.783 | 30.5 | 1.448 | 88.24 | 86.38 | |
| ProteinMPNN2025.06 | 81.6 | 40.5 | 35.778 | 27.057 | 82.361 | 29.7 | 1.469 | 86.64 | 84.67 | |
| ESM-IF2025.06 | 80.2 | 44.6 | 32.125 | 24.816 | 82.042 | 27.9 | 1.487 | 86.09 | 82.81 |