Protein sequence design on CATH 4.3 (test)
3.97RMSDTest Dataset
Evaluation Results
| Method | Links | |||||||
|---|---|---|---|---|---|---|---|---|
| Test Dataset2026.03 | 3.97 | 76.1 | 80.8 | 5.8 | 62 | 24.6 | 100 | |
| ProteinMPNN2026.03 | 4.3 | 74 | 79.1 | 6.7 | 71.9 | 76.9 | 38.9 | |
| Guidancetarget=Thermo2026.03 | 4.3 | 73.7 | 77.6 | 6.88 | 73.5 | 90.1 | 38.6 | |
| MoMPNNobjectives=Thermo+TM2026.03 | 4.3 | 73.9 | 78.4 | 6.24 | 70.4 | 94.7 | 38.6 | |
| MoMPNNobjectives=Thermo+TM+EP2026.03 | 4.3 | 74.2 | 78.6 | 6.12 | 73.1 | 94.6 | 38.7 | |
| Guidancetarget=Sol2026.03 | 4.33 | 74 | 79.4 | 6.4 | 76.2 | 80.5 | 39.3 | |
| ESM-IF2026.03 | 4.36 | 73.7 | 78.4 | 6.11 | 73.3 | 71.9 | 46.4 | |
| MoMPNNobjectives=Sol+TM2026.03 | 4.37 | 73.8 | 79.3 | 6.27 | 88.4 | 74.7 | 38.4 | |
| MoMPNNobjectives=Thermo+IG+EP2026.03 | 4.37 | 73.7 | 78.5 | 5.97 | 72.3 | 94.7 | 38.5 | |
| MoMPNNobjectives=Sol+TM+EP2026.03 | 4.38 | 73.9 | 79.5 | 6.18 | 85.2 | 79 | 38.7 | |
| MoMPNNobjectives=Thermo+IG2026.03 | 4.38 | 73.4 | 78.2 | 5.85 | 69.4 | 96.3 | 38.2 | |
| SolubleMPNN2026.03 | 4.48 | 73.3 | 78.8 | 6.54 | 79.4 | 81.5 | 38.2 | |
| MoMPNNobjectives=Sol+IG+EP2026.03 | 4.61 | 73.1 | 79.3 | 5.99 | 85.6 | 78.9 | 38.4 | |
| MoMPNNobjectives=Sol+IG2026.03 | 4.73 | 72.7 | 79.3 | 6 | 88.3 | 75.1 | 38.2 | |
| HyperMPNN2026.03 | 4.9 | 70.6 | 74.3 | 7.81 | 71.9 | 92.9 | 35.9 | |
| ProteinDPO2026.03 | 5.49 | 66.7 | 72 | 10.5 | 62.9 | 35.7 | 38.8 | |
| InstructPLMvariant=default2026.03 | 6.81 | 62.8 | 73.4 | 7.97 | 65.3 | 39.6 | 57.4 | |
| InstructPLMT=0.12026.03 | 6.96 | 63.2 | 74.4 | 7.31 | 65.7 | 45.5 | 58.4 |