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Mutational effect prediction on ProteinGym DMS >2 mutations set (4 mutation split)

0.615Spearman Correlationrd-ESM-2
0.535960.556480.5770.59752Mar 8, 2026

Evaluation results

MethodLinks
rd-ESM-2Model Scale=15B, Reverse Distillation=true2026.030.615
rd-ESM-2Model Scale=3B, Reverse Distillation=true2026.030.576
ESM-2Model Scale=15B, Reverse Distillation=false2026.030.566
ESM-2Model Scale=650M, Reverse Distillation=false2026.030.555
ESM-2Model Scale=3B, Reverse Distillation=false2026.030.552
rd-ESM-2Model Scale=650M, Reverse Distillation=true2026.030.539