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Mutational effect prediction on ProteinGym DMS 1 and 2 mutation set (2 mutation)

0.72Spearman Correlationrd-ESM-2
0.59520.62760.660.6924Mar 8, 2026

Evaluation results

MethodLinks
rd-ESM-2Model Scale=15B, Reverse Distillation=true2026.030.72
ESM-2Model Scale=15B, Reverse Distillation=false2026.030.714
rd-ESM-2Model Scale=3B, Reverse Distillation=true2026.030.697
rd-ESM-2Model Scale=650M, Reverse Distillation=true2026.030.688
rd-ESM-2Model Scale=15B, Reverse Distillation=true2026.030.677
ESM-2Model Scale=650M, Reverse Distillation=false2026.030.672
ESM-2Model Scale=3B, Reverse Distillation=false2026.030.672
ESM-2Model Scale=15B, Reverse Distillation=false2026.030.653
rd-ESM-2Model Scale=3B, Reverse Distillation=true2026.030.643
ESM-2Model Scale=3B, Reverse Distillation=false2026.030.621
ESM-2Model Scale=650M, Reverse Distillation=false2026.030.608
rd-ESM-2Model Scale=650M, Reverse Distillation=true2026.030.6