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Mutational effect prediction on ProteinGym DMS 1 and 2 mutation set (1 mutation)

0.904Spearman Correlationrd-ESM-2
0.51920.61910.7190.8189Mar 8, 2026

Evaluation results

MethodLinks
rd-ESM-2Model Scale=15B, Reverse Distillation=true2026.030.904
ESM-2Model Scale=15B, Reverse Distillation=false2026.030.899
rd-ESM-2Model Scale=3B, Reverse Distillation=true2026.030.893
rd-ESM-2Model Scale=650M, Reverse Distillation=true2026.030.885
ESM-2Model Scale=3B, Reverse Distillation=false2026.030.881
ESM-2Model Scale=650M, Reverse Distillation=false2026.030.879
ESM-2Model Scale=3B, Reverse Distillation=false2026.030.591
rd-ESM-2Model Scale=15B, Reverse Distillation=true2026.030.58
ESM-2Model Scale=15B, Reverse Distillation=false2026.030.579
rd-ESM-2Model Scale=3B, Reverse Distillation=true2026.030.574
rd-ESM-2Model Scale=650M, Reverse Distillation=true2026.030.55
ESM-2Model Scale=650M, Reverse Distillation=false2026.030.534