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ResearchFormerly WizWand

Catalytic Activity Prediction on Enzyme

0.58Spearman CorrelationAMPLIFY-120M Baseline
0.36160.41830.4750.5317May 8, 2026
Updated 5mo ago

Evaluation results

MethodLinks
AMPLIFY-120M BaselineBackbone=AMPLIFY-120M, Objective=Baseline2026.050.58
AMPLIFY-120M All-pos MLM+JEPABackbone=AMPLIFY-120M, Objective=All-pos MLM+JEPA2026.050.571
AMPLIFY-120M MLM-onlyBackbone=AMPLIFY-120M, Objective=MLM-only2026.050.567
AMPLIFY-120M Masked-posBackbone=AMPLIFY-120M, Objective=Masked-pos2026.050.557
ESM2-150M MLM-onlyBackbone=ESM2-150M, Objective=MLM-only2026.050.55
ESM2-35M Masked-pos (SGDm)Backbone=ESM2-35M, Objective=Masked-pos (SGDm)2026.050.549
ESM2-150M All-pos MLM+JEPABackbone=ESM2-150M, Objective=All-pos MLM+JEPA2026.050.548
ESM2-150M BaselineBackbone=ESM2-150M, Objective=Baseline2026.050.547
ESM2-150M Masked-pos (run 1)Backbone=ESM2-150M, Objective=Masked-pos (run 1)2026.050.547
ESM2-35M BaselineBackbone=ESM2-35M, Objective=Baseline2026.050.544
ESM2-150M Masked-pos (run 2)Backbone=ESM2-150M, Objective=Masked-pos (run 2)2026.050.543
ESM2-150M EMA (4h) EMABackbone=ESM2-150M EMA (4h), Objective=EMA2026.050.538
ESM2-35M Masked-pos (AdamW)Backbone=ESM2-35M, Objective=Masked-pos (AdamW)2026.050.533
MLM+JEPA @90kBackbone=-, Objective=MLM+JEPA @90k2026.050.526
ESM2-35M MLM-onlyBackbone=ESM2-35M, Objective=MLM-only2026.050.515
Rand-Init-35M MLM-onlyBackbone=Rand-Init-35M, Objective=MLM-only2026.050.508
ProteinBERT2-150M masked-posBackbone=-, Objective=ProteinBERT2-150M masked-pos2026.050.506
ProteinBERT2-35M Masked-posBackbone=ProteinBERT2-35M, Objective=Masked-pos2026.050.494
ProteinBERT2-35M MLM-onlyBackbone=ProteinBERT2-35M, Objective=MLM-only2026.050.478
ESM2-35M All-pos MLM+JEPABackbone=ESM2-35M, Objective=All-pos MLM+JEPA2026.050.473
Rand-Init-35M Masked-posBackbone=Rand-Init-35M, Objective=Masked-pos2026.050.468
ProteinBERT2-35M All-pos MLM+JEPABackbone=ProteinBERT2-35M, Objective=All-pos MLM+JEPA2026.050.465
Rand-Init-35M All-pos MLM+JEPABackbone=Rand-Init-35M, Objective=All-pos MLM+JEPA2026.050.462
ESM2-150M rand-init MLM-onlyBackbone=-, Objective=ESM2-150M rand-init MLM-only2026.050.461
Rand-Init-35M JEPA-onlyBackbone=Rand-Init-35M, Objective=JEPA-only2026.050.46
ProteinBERT2-35M BaselineBackbone=ProteinBERT2-35M, Objective=Baseline2026.050.442
JEPA-only @90kBackbone=-, Objective=JEPA-only @90k2026.050.442
AMPLIFY-120M JEPA-onlyBackbone=AMPLIFY-120M, Objective=JEPA-only2026.050.437
Rand-Init-35M BaselineBackbone=Rand-Init-35M, Objective=Baseline2026.050.432
ESM2-150M JEPA-onlyBackbone=ESM2-150M, Objective=JEPA-only2026.050.415
ESM2-35M JEPA-onlyBackbone=ESM2-35M, Objective=JEPA-only2026.050.391
ProteinBERT2-35M JEPA-onlyBackbone=ProteinBERT2-35M, Objective=JEPA-only2026.050.37