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Protein Stability Change Prediction on S8754

0.64Spearman CorrelationSPURS
0.14080.27040.40.5296Jun 6, 2026

Evaluation results

MethodLinks
SPURS2026.060.64
Constraint-Aware Optimization Frameworkobjective=full three-component objective (BMC + Siamese + OOD-margin)2026.060.628
ThermoMPNN2026.060.61
ProteinMPNN2026.060.24
ESM2026.060.16