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Protein Stability Change Prediction on S783

0.71Spearman CorrelationSPURS
0.28360.39430.5050.6157Jun 6, 2026

Evaluation results

MethodLinks
SPURS2026.060.71
ThermoMPNN2026.060.7
Constraint-Aware Optimization Frameworkobjective=full three-component objective (BMC + Siamese + OOD-margin)2026.060.697
ProteinMPNN2026.060.52
ESM2026.060.3