Protein-Protein Interaction Prediction on Human PPI
89.87AccuracyPROTLLM
Evaluation results
| Method | Links | ||
|---|---|---|---|
| PROTLLMPre-training (Protein)=true, Pre-training (Text)=true2024.02 | 89.87 | — | |
| ProtSTPre-training (Protein)=true, Pre-training (Text)=true2024.02 | 88.19 | — | |
| ESM-1b#Params=652.4M, Evaluation Protocol=only tuning the prediction head2023.10 | 88.06 | — | |
| ESM-2Pre-training (Protein)=true, Pre-training (Text)=false2024.02 | 86.9 | — | |
| BioT5#Params=252.1M2023.10 | 86.22 | — | |
| ProtBert#Params=419.9M, Evaluation Protocol=only tuning the prediction head2023.10 | 83.61 | — | |
| ESM-1bPre-training (Protein)=true, Pre-training (Text)=false2024.02 | 82.22 | — | |
| ESM-1b#Params=652.4M, Evaluation Protocol=fine-tuning2023.10 | 78.17 | — | |
| ProtBertPre-training (Protein)=true, Pre-training (Text)=false2024.02 | 77.32 | — | |
| ProtBert#Params=419.9M, Evaluation Protocol=fine-tuning2023.10 | 77.32 | — | |
| GearNetPre-training (Protein)=true, Pre-training (Text)=false2024.02 | 73.86 | — | |
| OntoProteinPre-training (Protein)=true, Pre-training (Text)=true2024.02 | 70.42 | — | |
| ResNet#Params=11.0M2023.10 | 68.61 | — | |
| LSTM#Params=26.7M2023.10 | 63.75 | — | |
| DDE#Params=205.3K2023.10 | 62.77 | — | |
| CNN#Params=5.4M2023.10 | 62.6 | — | |
| Transformer#Params=21.3M2023.10 | 59.58 | — | |
| Moran#Params=123.4K2023.10 | 54.67 | — | |
| BIOARC (con-ft)#Param=2.49M, #Data=2.1B2025.11 | — | 77.22 | |
| BIOARC (mask-ft)#Param=3.14M, #Data=2.1B2025.11 | — | 74.26 | |
| BIOARC (only-ft)#Param=2.88M, #Data=0B2025.11 | — | 80.59 | |
| ESM-1b#Param=652.4M, #Data=86B2025.11 | — | 78.17 | |
| ESM22026.07 | — | 77 | |
| ESM2-1b#Param=652.4M, #Data=86B2025.11 | — | 80.49 | |
| ESM2-8m#Param=8M, #Data=86B2025.11 | — | 80.16 | |
| ProtBert#Param=419.9M, #Data=393B2025.11 | — | 77.32 | |
| SciReasoner2026.07 | — | 73 |