Protein-ligand binding prediction on DAVIS
92.5AUCDrugCLIP‡
Evaluation results
| Method | Links | ||
|---|---|---|---|
| DrugCLIP‡Mechanism type=latent contrastive, Note=Structure-informed2026.06 | 92.5 | 47.3 | |
| w/ LOGICA†Backbone=SELFormer–ESM-2, Mechanism type=token-score contrastive2026.06 | 92.4 | 44.6 | |
| SP-DTI‡Mechanism type=classifier head, Note=Structure-informed2026.06 | 92.4 | 42.4 | |
| GS-DTI‡Mechanism type=latent contrastive, Note=Structure-informed2026.06 | 91.6 | 43 | |
| w/ LatentCABackbone=SELFormer–ESM-2, Mechanism type=latent contrastive2026.06 | 90.4 | 37.1 | |
| MolTransMechanism type=classifier head2026.06 | 90.1 | 34.3 | |
| ConPLexMechanism type=latent contrastive2026.06 | 88.7 | 44.1 | |
| DrugBANMechanism type=classifier head2026.06 | 88.3 | 34.9 | |
| w/ LOGIMLM†Backbone=SELFormer–ESM-2, Mechanism type=logit-level MLM2026.06 | 73.9 | 19.7 |