Drug-resistance variant scoring on Coelho 10g
0.271RhoLOGICA
Evaluation results
| Method | Links | ||
|---|---|---|---|
| LOGICAProtocol=Contextualized backbone (fine-tuned), Model Capacity=150M, Scoring Interface=token-score contrastive2026.06 | 0.271 | 0.644 | |
| LOGIMLMProtocol=Contextualized backbone (fine-tuned), Model Capacity=150M, Scoring Interface=logit-level MLM2026.06 | 0.258 | 0.632 | |
| LOGICAProtocol=Contextualized backbone (fine-tuned), Model Capacity=35M, Scoring Interface=token-score contrastive2026.06 | 0.256 | 0.636 | |
| LOGIMLMProtocol=Contextualized backbone (fine-tuned), Model Capacity=35M, Scoring Interface=logit-level MLM2026.06 | 0.214 | 0.613 | |
| EVEProtocol=Unconditional baselines, Scoring Interface=MSA VAE2026.06 | 0.114 | 0.568 | |
| LatentFuseProtocol=Contextualized backbone (fine-tuned), Model Capacity=35M, Scoring Interface=concat embeddings + MLP2026.06 | 0.091 | 0.547 | |
| ESM-1vProtocol=Unconditional baselines, Scoring Interface=masked LM2026.06 | 0.076 | 0.54 | |
| LatentFuseProtocol=Contextualized backbone (fine-tuned), Model Capacity=150M, Scoring Interface=concat embeddings + MLP2026.06 | 0.059 | 0.536 | |
| ESM-2Protocol=Unconditional baselines, Model Capacity=150M, Scoring Interface=masked LM2026.06 | 0.052 | 0.532 | |
| TranceptionProtocol=Unconditional baselines, Scoring Interface=retrieval LM2026.06 | 0.041 | 0.525 | |
| ESM-2Protocol=Unconditional baselines, Model Capacity=35M, Scoring Interface=masked LM2026.06 | 0.024 | 0.516 | |
| Boltz-2Protocol=Contextualized baselines (fine-tuned), Scoring Interface=structure features + MLP2026.06 | 0.015 | 0.506 | |
| DrugBANProtocol=Contextualized baselines (fine-tuned), Scoring Interface=DTI classifier + MLP2026.06 | 0.014 | 0.52 | |
| DrugCLIPProtocol=Contextualized baselines (fine-tuned), Scoring Interface=DTI contrastive + MLP2026.06 | 0.001 | 0.505 |