Drug-resistance variant scoring on Kim EGFR
0.295Correlation Coefficient (rho)LOGICA
Evaluation Results
| Method | Links | ||
|---|---|---|---|
| LOGICAProtocol=Contextualized backbone (fine-tuned), Model Capacity=150M, Scoring Interface=token-score contrastive2026.06 | 0.295 | 63.8 | |
| LOGIMLMProtocol=Contextualized backbone (fine-tuned), Model Capacity=150M, Scoring Interface=logit-level MLM2026.06 | 0.272 | 63.3 | |
| LOGICAProtocol=Contextualized backbone (fine-tuned), Model Capacity=35M, Scoring Interface=token-score contrastive2026.06 | 0.26 | 63 | |
| LOGIMLMProtocol=Contextualized backbone (fine-tuned), Model Capacity=35M, Scoring Interface=logit-level MLM2026.06 | 0.245 | 62 | |
| ESM-1vProtocol=Unconditional baselines, Scoring Interface=masked LM2026.06 | 0.195 | 60.1 | |
| TranceptionProtocol=Unconditional baselines, Scoring Interface=retrieval LM2026.06 | 0.17 | 59.1 | |
| EVEProtocol=Unconditional baselines, Scoring Interface=MSA VAE2026.06 | 0.156 | 58 | |
| ESM-2Protocol=Unconditional baselines, Model Capacity=35M, Scoring Interface=masked LM2026.06 | 0.155 | 57.7 | |
| ESM-2Protocol=Unconditional baselines, Model Capacity=150M, Scoring Interface=masked LM2026.06 | 0.153 | 58 | |
| LatentFuseProtocol=Contextualized backbone (fine-tuned), Model Capacity=35M, Scoring Interface=concat embeddings + MLP2026.06 | 0.029 | 51.9 | |
| LatentFuseProtocol=Contextualized backbone (fine-tuned), Model Capacity=150M, Scoring Interface=concat embeddings + MLP2026.06 | 0.019 | 51.1 | |
| DrugBANProtocol=Contextualized baselines (fine-tuned), Scoring Interface=DTI classifier + MLP2026.06 | 0.018 | 50.7 | |
| Boltz-2Protocol=Contextualized baselines (fine-tuned), Scoring Interface=structure features + MLP2026.06 | 0.011 | 50.6 | |
| DrugCLIPProtocol=Contextualized baselines (fine-tuned), Scoring Interface=DTI contrastive + MLP2026.06 | 0 | 49.7 |