Perturbation prediction on Replogle
0.039DEOverSquidiff
Evaluation Results
| Method | Links | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Squidiff2026.02 | 0.039 | -10.19 | 0.091 | 0.419 | 0.432 | 0 | 0.079 | 0.366 | 0.089 | 4.641 | 2.077 | 0.5 | 0.501 | 0.501 | |
| Squidiffprotocol=Few-shot2026.03 | 0.039 | — | 0.091 | — | 0.432 | 0 | — | — | 0.089 | 4.641 | 2.077 | — | — | — | |
| Linear2026.02 | 0.068 | 0.991 | 0.074 | 0.353 | 0.535 | 0.056 | 0.085 | 0.435 | 0.058 | 0.013 | 0.074 | 0.519 | 0.517 | 0.667 | |
| Linearprotocol=Few-shot2026.03 | 0.068 | — | 0.074 | — | 0.535 | 0.056 | — | — | 0.058 | 0.013 | 0.074 | — | — | — | |
| CellFlow2026.02 | 0.11 | 0.757 | 0.093 | 0.442 | 0.472 | -0.033 | 0.086 | 0.434 | -0.003 | 0.0949 | 0.205 | 0.507 | 0.507 | 0.495 | |
| Mean Variantaggregation_level=per Batch2026.02 | 0.11 | 0.798 | 0.092 | 0.421 | 0.475 | -0.024 | 0.088 | 0.45 | 0.002 | 0.0699 | 0.174 | 0.505 | 0.505 | 0.506 | |
| CellFlowprotocol=Few-shot2026.03 | 0.11 | — | 0.093 | — | 0.472 | -0.033 | — | — | -0.003 | 0.0949 | 0.205 | — | — | — | |
| Mean Variant (per Batch)protocol=Few-shot2026.03 | 0.11 | — | 0.092 | — | 0.475 | -0.024 | — | — | 0.002 | 0.0699 | 0.174 | — | — | — | |
| Mean Variantaggregation_level=Overall2026.02 | 0.111 | 0.794 | 0.093 | 0.416 | 0.474 | -0.027 | 0.089 | 0.453 | -0.001 | 0.0711 | 0.175 | 0.502 | 0.503 | 0.501 | |
| Mean Variant (Overall)protocol=Few-shot2026.03 | 0.111 | — | 0.093 | — | 0.474 | -0.027 | — | — | -0.001 | 0.0711 | 0.175 | — | — | — | |
| Mean2026.02 | 0.127 | 0.742 | 0.094 | 0.417 | 0.532 | 0.077 | 0.092 | 0.467 | 0.048 | 0.099 | 0.206 | 0.582 | 0.599 | 0.608 | |
| Meanprotocol=Few-shot2026.03 | 0.127 | — | 0.094 | — | 0.532 | 0.077 | — | — | 0.048 | 0.099 | 0.206 | — | — | — | |
| CPA2026.02 | 0.173 | 1 | 0.087 | 0.637 | 0.746 | 0.499 | 0.081 | 0.401 | 0.418 | 0.075 | 0.054 | 0.582 | 0.581 | 0.521 | |
| CPAprotocol=Few-shot2026.03 | 0.173 | — | 0.087 | — | 0.746 | 0.499 | — | — | 0.418 | 0.075 | 0.054 | — | — | — | |
| Mean Variantaggregation_level=per Cell Type2026.02 | 0.178 | 1 | 0.087 | 0.417 | 0.743 | 0.492 | 0.078 | 0.404 | 0.412 | 0.0085 | 0.057 | 0.502 | 0.505 | 0.502 | |
| Mean Variant (per Cell Type)protocol=Few-shot2026.03 | 0.178 | — | 0.087 | — | 0.743 | 0.492 | — | — | 0.412 | 0.0085 | 0.057 | — | — | — | |
| PerturbDifftraining_protocol=Scratch2026.02 | 0.19 | 0.984 | 0.174 | 0.623 | 0.702 | 0.342 | 0.21 | 0.625 | 0.34 | 0.0147 | 0.081 | 0.69 | 0.7 | 0.575 | |
| PerturbDiffprotocol=Few-shot2026.03 | 0.19 | — | 0.174 | — | 0.702 | 0.342 | — | — | 0.34 | 0.0147 | 0.081 | — | — | — | |
| STATE2026.02 | 0.196 | 0.998 | 0.193 | 0.818 | 0.778 | 0.506 | 0.239 | 0.633 | 0.437 | 0.0064 | 0.055 | 0.788 | 0.802 | 0.676 | |
| STATEimplementation=reproduced, protocol=Few-shot2026.03 | 0.196 | — | 0.193 | — | 0.778 | 0.506 | — | — | 0.437 | 0.0064 | 0.055 | — | — | — | |
| PerturbDifftraining_protocol=Finetuned2026.02 | 0.214 | 0.988 | 0.192 | 0.762 | 0.723 | 0.388 | 0.257 | 0.652 | 0.376 | 0.0146 | 0.079 | 0.758 | 0.762 | 0.639 | |
| SCALEimplementation=reproduced, protocol=Few-shot2026.03 | 0.601 | — | 0.345 | — | 0.979 | 0.871 | — | — | 0.909 | 0.0009 | 0.072 | — | — | — |