Mutational fitness prediction on ProteinGym 96 DMS assays L <= 200
0.518Spearman CorrelationENSEMBITS + ESM2
Evaluation results
| Method | Links | |||
|---|---|---|---|---|
| ENSEMBITS + ESM2Blending strategy=within-assay z-score blend, alpha=0.3, Input backbone=ESMFold-predicted atom14, P=12026.05 | 0.518 | 0.033 | 6.9 | |
| AminoAseed + ESM2Blending strategy=within-assay z-score blend, alpha=0.3, Input backbone=ESMFold-predicted atom142026.05 | 0.517 | 0.033 | 6.8 | |
| ESM3struct + ESM2Blending strategy=within-assay z-score blend, alpha=0.3, Input backbone=ESMFold-predicted atom142026.05 | 0.515 | 0.03 | 6.3 | |
| ProToken + ESM2Blending strategy=within-assay z-score blend, alpha=0.3, Input backbone=ESMFold-predicted atom142026.05 | 0.508 | 0.023 | 4.8 | |
| 3di_tokens + ESM2Blending strategy=within-assay z-score blend, alpha=0.3, Input backbone=ESMFold-predicted atom142026.05 | 0.507 | 0.023 | 4.6 | |
| ESM2-650MMode=standalone2026.05 | 0.484 | — | — | |
| ESM3structBlending strategy=None, Input backbone=ESMFold-predicted atom142026.05 | 0.384 | -0.1 | -20.7 | |
| ENSEMBITSBlending strategy=None, Input backbone=ESMFold-predicted atom14, P=12026.05 | 0.381 | -0.104 | -21.4 | |
| AminoAseedBlending strategy=None, Input backbone=ESMFold-predicted atom142026.05 | 0.366 | -0.118 | -24.4 | |
| ProTokenBlending strategy=None, Input backbone=ESMFold-predicted atom142026.05 | 0.358 | -0.126 | -26 | |
| 3di_tokens (Foldseek/mini3di)Blending strategy=None, Input backbone=ESMFold-predicted atom142026.05 | 0.327 | -0.157 | -32.4 |