Molecular Optimization (QED) on TOMG-Bench benchmark leaderboard · SOTA2 Research

Molecular Optimization (QED) on TOMG-Bench

76.5Success Rate (SR)MolLingo

Evaluation Results

Method	Links
MolLingo2026.05		76.5	54.6	41.8
OpenMolIns-xlarge2026.05		57.86	56.77	32.8
REINVENT2026.03		55.8	11.5	5.8
Claude-3.52026.05		53.61	70.42	37.8
OpenMolIns-large2026.05		52.24	63.98	33.4
Bio-T5-base2026.03		50.7	15.8	8
BioT5-base2026.05		50.68	15.8	8
MOLLEO2026.03		49.6	12.2	6.1
OpenMolIns-large2026.05		49.5	59.62	29.5
Graph GA2026.03		49.3	14	6.4
Gemini-1.5-pro2026.05		47.04	60.77	28.6
Claude-32026.05		46.78	58.55	27.4
MolT5-large2026.05		46.54	11.9	5.5
Mol-T5-large2026.03		46.5	11.9	5.5
OpenMolIns-medium2026.05		46.08	58.59	27
GPT-5.42026.05		43.2	28.4	12.3
GPT-4o2026.05		39.52	61.8	24.4
GPT-4-turbo2026.05		39.46	65.87	25.6
GPT-3.5-turbo2026.05		33.16	56.35	18.7
RePO2026.03		31.2	75.6	23.6
RePO2026.05		31.2	75.6	23.6
SFT2026.03		29.7	69.7	20.7
OpenMolIns-small2026.05		29.56	63.85	18.9
Llama3-70B-Instruct2026.05		27.74	48.28	13.4
OpenMolIns-light2026.05		26.9	65.21	17.5
Llama3.1-8B-Instruct2026.05		26.55	44.99	11.9
Llama3-8B-Instruct2026.05		25.68	45.47	11.7
MolT5-base2026.05		23.58	10.54	2.5
GPT-4o-mini2026.03		23.1	75.2	17.4
GRPO2026.03		22.3	86.3	19.3
MolT5-small2026.05		22.14	10.31	2.3
OpenMolIns-large2026.05		19.96	58.49	11.7
Baseline2026.03		18.8	69.3	13
Chatglm-9B2026.05		18.32	65.06	11.9
GRPO2026.03		13.8	88.9	12.3
Mistral-7B-Instruct-v0.22026.05		12.1	32.44	3.9
Yi-1.5-9B2026.05		10.64	65.96	7
Llama-3.2-1B-Instruct2026.05		7.14	47.57	3.4
Qwen2-7B-Instruct2026.05		0	0	0