Molecular Optimization (QED) on TOMG-Bench
76.5Success Rate (SR)MolLingo
Evaluation results
| Method | Links | |||
|---|---|---|---|---|
| MolLingobase model=GPT-5.4 base2026.05 | 76.5 | 54.6 | 41.8 | |
| OpenMolIns-xlargebackbone=Gal-125M2026.05 | 57.86 | 56.77 | 32.8 | |
| REINVENT2026.03 | 55.8 | 11.5 | 5.8 | |
| Claude-3.52026.05 | 53.61 | 70.42 | 37.8 | |
| OpenMolIns-largebackbone=Llama-3.1-8B2026.05 | 52.24 | 63.98 | 33.4 | |
| Bio-T5-base2026.03 | 50.7 | 15.8 | 8 | |
| BioT5-base2026.05 | 50.68 | 15.8 | 8 | |
| MOLLEO2026.03 | 49.6 | 12.2 | 6.1 | |
| OpenMolIns-largebackbone=Galactica-125M2026.05 | 49.5 | 59.62 | 29.5 | |
| Graph GA2026.03 | 49.3 | 14 | 6.4 | |
| Gemini-1.5-pro2026.05 | 47.04 | 60.77 | 28.6 | |
| Claude-32026.05 | 46.78 | 58.55 | 27.4 | |
| MolT5-large2026.05 | 46.54 | 11.9 | 5.5 | |
| Mol-T5-large2026.03 | 46.5 | 11.9 | 5.5 | |
| OpenMolIns-mediumbackbone=Gal-125M2026.05 | 46.08 | 58.59 | 27 | |
| GPT-5.42026.05 | 43.2 | 28.4 | 12.3 | |
| GPT-4o2026.05 | 39.52 | 61.8 | 24.4 | |
| GPT-4-turbo2026.05 | 39.46 | 65.87 | 25.6 | |
| GPT-3.5-turbo2026.05 | 33.16 | 56.35 | 18.7 | |
| RePO2026.03 | 31.2 | 75.6 | 23.6 | |
| RePO2026.05 | 31.2 | 75.6 | 23.6 | |
| SFT2026.03 | 29.7 | 69.7 | 20.7 | |
| OpenMolIns-smallbackbone=Galactica-125M2026.05 | 29.56 | 63.85 | 18.9 | |
| Llama3-70B-Instruct2026.05 | 27.74 | 48.28 | 13.4 | |
| OpenMolIns-lightbackbone=Galactica-125M2026.05 | 26.9 | 65.21 | 17.5 | |
| Llama3.1-8B-Instruct2026.05 | 26.55 | 44.99 | 11.9 | |
| Llama3-8B-Instruct2026.05 | 25.68 | 45.47 | 11.7 | |
| MolT5-base2026.05 | 23.58 | 10.54 | 2.5 | |
| GPT-4o-mini2026.03 | 23.1 | 75.2 | 17.4 | |
| GRPOinitialization=SFT-Init2026.03 | 22.3 | 86.3 | 19.3 | |
| MolT5-small2026.05 | 22.14 | 10.31 | 2.3 | |
| OpenMolIns-largebackbone=Llama-3.2-1B2026.05 | 19.96 | 58.49 | 11.7 | |
| Baselinebackbone=Qwen 2.5-3B Instruct2026.03 | 18.8 | 69.3 | 13 | |
| Chatglm-9B2026.05 | 18.32 | 65.06 | 11.9 | |
| GRPO2026.03 | 13.8 | 88.9 | 12.3 | |
| Mistral-7B-Instruct-v0.22026.05 | 12.1 | 32.44 | 3.9 | |
| Yi-1.5-9B2026.05 | 10.64 | 65.96 | 7 | |
| Llama-3.2-1B-Instruct2026.05 | 7.14 | 47.57 | 3.4 | |
| Qwen2-7B-Instruct2026.05 | 0 | 0 | 0 |