Molecular Optimization (LogP) on TOMG-Bench
96.8Success Rate (SR)MolLingo
Evaluation results
| Method | Links | |||
|---|---|---|---|---|
| MolLingobase model=GPT-5.4 base2026.05 | 96.8 | 73 | 70.6 | |
| GPT-5.42026.05 | 87.1 | 61.2 | 53.3 | |
| OpenMolIns-largebackbone=Llama-3.1-8B2026.05 | 80.54 | 66.78 | 53.8 | |
| Claude-32026.05 | 79.84 | 60.67 | 48.4 | |
| Claude-3.52026.05 | 79.7 | 71.24 | 56.8 | |
| Gemini-1.5-pro2026.05 | 77.12 | 70.22 | 54.2 | |
| GPT-4-turbo2026.05 | 76.62 | 69.84 | 53.5 | |
| OpenMolIns-xlargebackbone=Gal-125M2026.05 | 73.62 | 57.44 | 42.3 | |
| GPT-4o2026.05 | 71.9 | 65.9 | 47.4 | |
| OpenMolIns-largebackbone=Galactica-125M2026.05 | 64.54 | 59.27 | 38.3 | |
| Llama3-70B-Instruct2026.05 | 59.84 | 60.28 | 36.1 | |
| OpenMolIns-mediumbackbone=Gal-125M2026.05 | 59.04 | 58.12 | 34.3 | |
| Bio-T5-base2026.03 | 51.6 | 15.3 | 7.9 | |
| BioT5-base2026.05 | 51.58 | 15.26 | 7.9 | |
| MOLLEO2026.03 | 51 | 10.3 | 5.3 | |
| Graph GA2026.03 | 50.9 | 12.5 | 6.4 | |
| GPT-4o-mini2026.03 | 49.9 | 70.6 | 35.2 | |
| REINVENT2026.03 | 46.5 | 12.5 | 5.8 | |
| Llama3-8B-Instruct2026.05 | 46.42 | 36.58 | 17 | |
| MolT5-large2026.05 | 42.44 | 10.15 | 4.3 | |
| Mol-T5-large2026.03 | 42.4 | 10.2 | 4.3 | |
| OpenMolIns-smallbackbone=Galactica-125M2026.05 | 41.72 | 64.2 | 26.8 | |
| RePO2026.03 | 41.5 | 71.5 | 29.7 | |
| RePO2026.05 | 41.5 | 71.5 | 29.7 | |
| GPT-3.5-turbo2026.05 | 40.48 | 63.27 | 25.6 | |
| Llama3.1-8B-Instruct2026.05 | 39.9 | 42.35 | 16.9 | |
| GRPO2026.03 | 37.9 | 80.6 | 30.5 | |
| Chatglm-9B2026.05 | 36.66 | 69.02 | 25.3 | |
| OpenMolIns-lightbackbone=Galactica-125M2026.05 | 32.02 | 65.47 | 21 | |
| SFT2026.03 | 29.8 | 69.2 | 20.6 | |
| OpenMolIns-largebackbone=Llama-3.2-1B2026.05 | 28.98 | 59.51 | 17.2 | |
| Yi-1.5-9B2026.05 | 28.84 | 54.61 | 15.7 | |
| Baselinebackbone=Qwen 2.5-3B Instruct2026.03 | 26.8 | 62.7 | 16.8 | |
| Mistral-7B-Instruct-v0.22026.05 | 22.2 | 45.01 | 10 | |
| MolT5-small2026.05 | 21.58 | 10.52 | 2.3 | |
| GRPOinitialization=SFT-Init2026.03 | 21.2 | 86.3 | 18.3 | |
| MolT5-base2026.05 | 20.74 | 10.51 | 2.2 | |
| Llama-3.2-1B-Instruct2026.05 | 6.44 | 50.55 | 3.3 | |
| Qwen2-7B-Instruct2026.05 | 0 | 29.23 | 0 |