Fitness Prediction on ProteinGym (overall)
0.519Spearman CorrelationEvoIF-MSA
Evaluation results
| Method | Links | |||||
|---|---|---|---|---|---|---|
| EvoIF-MSASeq.=true, Struct.=true, MSA=true, # Params.=76M, # Data=30K2025.10 | 0.519 | 78.4 | 0.409 | 79.6 | 24.6 | |
| VenusREMSeq.=true, Struct.=true, MSA=true, # Params.=110M, # Data=18.8M2025.10 | 0.518 | 78.3 | 0.404 | 77 | 24.4 | |
| AIDO Protein-RAGSeq.=true, Struct.=true, MSA=true, # Params.=16B, # Data=1.2T2025.10 | 0.518 | 78.4 | 0.405 | 78.9 | 23.9 | |
| ProtSST (K=2048)Seq.=true, Struct.=true, MSA=false, # Params.=110M, # Data=18.8M2025.10 | 0.507 | 77.7 | 0.398 | 77.4 | 23.6 | |
| S3F-MSASeq.=true, Struct.=true, Surf.=true, MSA=true, # Params.=260M, zero-shot=true2024.12 | 0.496 | 77.1 | 0.387 | 79.2 | 24.4 | |
| S3F-MSASeq.=true, Struct.=true, MSA=true, # Params.=260M, # Data=30K2025.10 | 0.496 | 77.1 | 0.387 | 79.2 | 24.4 | |
| EvoIFSeq.=true, Struct.=true, MSA=false, # Params.=76M, # Data=30K2025.10 | 0.489 | 76.8 | 0.384 | 78.2 | 25 | |
| S2F-MSASeq.=true, Struct.=true, Surf.=false, MSA=true, # Params.=246M, zero-shot=true2024.12 | 0.487 | 76.7 | 0.381 | 79 | 24 | |
| S2F-MSASeq.=true, Struct.=true, MSA=true, # Params.=246M, # Data=30K2025.10 | 0.487 | 76.7 | 0.381 | 79 | 24 | |
| S3FSeq.=true, Struct.=true, Surf.=true, MSA=false, # Params.=20M, zero-shot=true2024.12 | 0.47 | 75.7 | 0.371 | 77 | 23.4 | |
| S3FSeq.=true, Struct.=true, MSA=false, # Params.=20M, # Data=30K2025.10 | 0.47 | 75.7 | 0.371 | 77 | 23.4 | |
| SaProtSeq.=true, Struct.=true, Surf.=false, MSA=false, # Params.=650M2024.12 | 0.457 | 75.1 | 0.359 | 76.8 | 23.3 | |
| SaProtSeq.=true, Struct.=true, MSA=false, # Params.=650M, # Data=40M2025.10 | 0.457 | 75.1 | 0.359 | 76.8 | 23.3 | |
| TranceptEVE LSeq.=true, Struct.=false, Surf.=false, MSA=true, # Params.=940M2024.12 | 0.456 | 75.1 | 0.356 | 78.6 | 23 | |
| TranceptEVE LSeq.=true, Struct.=false, MSA=true, # Params.=940M, # Data=250M2025.10 | 0.456 | 75.1 | 0.356 | 78.6 | 23 | |
| GEMMESeq.=true, Struct.=false, Surf.=false, MSA=true, # Params.=<1M2024.12 | 0.455 | 74.9 | 0.352 | 77.7 | 21.1 | |
| GEMMESeq.=true, Struct.=false, MSA=true, # Params.=<1M, # Data=N/A2025.10 | 0.455 | 74.9 | 0.352 | 77.7 | 21.1 | |
| S2FSeq.=true, Struct.=true, Surf.=false, MSA=false, # Params.=6M, zero-shot=true2024.12 | 0.454 | 74.9 | 0.359 | 76.2 | 22.7 | |
| S2FSeq.=true, Struct.=true, MSA=false, # Params.=6M, # Data=30K2025.10 | 0.454 | 74.9 | 0.359 | 76.2 | 22.7 | |
| ProtSSNSeq.=true, Struct.=true, Surf.=false, MSA=false, # Params.=148M2024.12 | 0.442 | 74.3 | 0.351 | 76.4 | 22.6 | |
| ProtSSNSeq.=true, Struct.=true, MSA=false, # Params.=148M, # Data=30K2025.10 | 0.442 | 74.3 | 0.351 | 76.4 | 22.6 | |
| EVESeq.=true, Struct.=false, Surf.=false, MSA=true, # Params.=240M2024.12 | 0.439 | 74.1 | 0.342 | 78.3 | 23 | |
| EVESeq.=true, Struct.=false, MSA=true, # Params.=240M, # Data=250M2025.10 | 0.439 | 74.1 | 0.342 | 78.3 | 23 | |
| MSA TransformerSeq.=true, Struct.=false, Surf.=false, MSA=true, # Params.=100M2024.12 | 0.434 | 73.8 | 0.34 | 77.9 | 22.4 | |
| Tranception LSeq.=true, Struct.=false, Surf.=false, MSA=true, # Params.=700M2024.12 | 0.434 | 73.9 | 0.341 | 77.9 | 22 | |
| MSA TransformerSeq.=true, Struct.=false, MSA=true, # Params.=100M, # Data=26M2025.10 | 0.434 | 73.8 | 0.34 | 77.9 | 22.4 | |
| Tranception LSeq.=true, Struct.=false, MSA=true, # Params.=700M, # Data=250M2025.10 | 0.434 | 73.9 | 0.341 | 77.9 | 22 | |
| ESM-IFSeq.=false, Struct.=true, Surf.=false, MSA=false, # Params.=142M2024.12 | 0.422 | 73 | 0.331 | 74.8 | 22.3 | |
| ESM-IFSeq.=false, Struct.=true, MSA=false, # Params.=142M, # Data=19K2025.10 | 0.422 | 73 | 0.331 | 74.8 | 22.3 | |
| DeepSequenceSeq.=true, Struct.=false, Surf.=false, MSA=true, # Params.=70M2024.12 | 0.419 | 72.9 | 0.328 | 77.6 | 22.6 | |
| DeepSequenceSeq.=true, Struct.=false, MSA=true, # Params.=70M, # Data=N/A2025.10 | 0.419 | 72.9 | 0.328 | 77.6 | 22.6 | |
| ESM2Seq.=true, Struct.=false, Surf.=false, MSA=false, # Params.=650M2024.12 | 0.414 | 72.9 | 0.327 | 74.7 | 21.7 | |
| ESM-2Seq.=true, Struct.=false, MSA=false, # Params.=650M, # Data=49M2025.10 | 0.414 | 72.9 | 0.327 | 74.7 | 21.7 | |
| ProGen2 XLSeq.=true, Struct.=false, Surf.=false, MSA=false, # Params.=6,400M2024.12 | 0.391 | 71.7 | 0.306 | 76.7 | 19.9 | |
| ProGen2 XLSeq.=true, Struct.=false, MSA=false, # Params.=6.4B, # Data=>1B2025.10 | 0.391 | 71.7 | 0.306 | 76.7 | 19.9 | |
| MIFSeq.=false, Struct.=true, Surf.=false, MSA=false, # Params.=3M2024.12 | 0.383 | 70.6 | 0.294 | 74.3 | 21.6 | |
| MIF-STSeq.=true, Struct.=true, Surf.=false, MSA=false, # Params.=643M2024.12 | 0.383 | 71.7 | 0.31 | 76.5 | 22.6 | |
| MIFSeq.=false, Struct.=true, MSA=false, # Params.=3M, # Data=19K2025.10 | 0.383 | 70.6 | 0.294 | 74.3 | 21.6 | |
| MIF-STSeq.=true, Struct.=true, MSA=false, # Params.=643M, # Data=19K2025.10 | 0.383 | 71.7 | 0.31 | 76.5 | 22.6 | |
| CARPSeq.=true, Struct.=false, Surf.=false, MSA=false, # Params.=640M2024.12 | 0.368 | 70.1 | 0.285 | 74.8 | 20.8 | |
| CARPSeq.=true, Struct.=false, MSA=false, # Params.=640M, # Data=41M2025.10 | 0.368 | 70.1 | 0.285 | 74.8 | 20.8 | |
| ProteinMPNNSeq.=false, Struct.=true, Surf.=false, MSA=false, # Params.=2M2024.12 | 0.258 | 63.9 | 0.196 | 71.3 | 18.6 | |
| ProteinMPNNSeq.=false, Struct.=true, MSA=false, # Params.=2M, # Data=25K2025.10 | 0.258 | 63.9 | 0.196 | 71.3 | 18.6 |