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Drug-Drug Interaction prediction research benchmarks – Page 3 · SOTA2 Research

Drug-Drug Interaction prediction

Benchmarks

Dataset NameSOTA MethodSort

Dataset NameSOTA methodMetricTrendResultsLast Updated

MARD PAIR-COLD (test)

Claude Sonnet 4.6

55.5Macro F1 Score

6

Jun 12, 2026

MARD DRUG-COLD (test)

52.5Macro-F1

6

Jun 12, 2026

MARD RANDOM-SPLIT WARM (test)

52.7Macro F1 Score

6

Jun 12, 2026

DDI Seen-Drug Setting

95.69Accuracy (ACC)

6

May 15, 2026

DDI dataset (Both-unseen)

GIL-DDI + AIM-DDI

58.12ACC

6

May 15, 2026

Twosides (transductive)

0.989AUC

6

Mar 27, 2026

OpenDDI 20 (PAIR-COLD)

54Family Macro F1

5

Jun 12, 2026

OpenDDI 20 (DRUG-COLD)

53.5Family macro-F1

5

Jun 12, 2026

OpenDDI RAND-FULL 20 (WARM)

87.6Macro F1 (Family)

5

Jun 12, 2026

TWOSIDES S2 tasks

72.27Thoroughness

2

Jul 1, 2026

DrugBank KGDB-DDI-based

97.8Accuracy

2

May 15, 2026

DrugBank KnowDDI-based

97.7Accuracy

2

May 15, 2026

Page 3 of 3

Popular datasets

DrugBank TWOSIDES DDInter Corpus DDI

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