Zero-shot Gene Inhibitor Prediction on 10 canonical genes inhibitor libraries (Unseen gene knockout)
88.1Morgan Fingerprint SimilarityCURE
Evaluation results
| Method | Links | ||
|---|---|---|---|
| CURETarget Gene=SMAD3, Evaluation Protocol=Zero-shot2026.05 | 88.1 | -9.07 | |
| Gex.Target Gene=SMAD3, Evaluation Protocol=Zero-shot2026.05 | 84.5 | -7.28 | |
| Gx2.Target Gene=SMAD3, Evaluation Protocol=Zero-shot2026.05 | 84.3 | -7.35 | |
| CURETarget Gene=TP53, Evaluation Protocol=Zero-shot2026.05 | 81.6 | -8.28 | |
| CURETarget Gene=PIK3CA, Evaluation Protocol=Zero-shot2026.05 | 80.9 | -9.15 | |
| Gex.Target Gene=TP53, Evaluation Protocol=Zero-shot2026.05 | 80.9 | -7.09 | |
| CURETarget Gene=MTOR, Evaluation Protocol=Zero-shot2026.05 | 80.8 | -8.74 | |
| CURETarget Gene=AKT1, Evaluation Protocol=Zero-shot2026.05 | 80.4 | -8.63 | |
| Gex.Target Gene=MTOR, Evaluation Protocol=Zero-shot2026.05 | 79.4 | -7.09 | |
| Gx2.Target Gene=TP53, Evaluation Protocol=Zero-shot2026.05 | 79.3 | -7.43 | |
| CURETarget Gene=EGFR, Evaluation Protocol=Zero-shot2026.05 | 78.2 | -9.11 | |
| CURETarget Gene=HDAC1, Evaluation Protocol=Zero-shot2026.05 | 77.2 | -8.68 | |
| Gex.Target Gene=PIK3CA, Evaluation Protocol=Zero-shot2026.05 | 76.4 | -7.33 | |
| CURETarget Gene=AURKB, Evaluation Protocol=Zero-shot2026.05 | 76 | -8.79 | |
| CURETarget Gene=AKT2, Evaluation Protocol=Zero-shot2026.05 | 75.4 | -8.59 | |
| CURETarget Gene=CTSK, Evaluation Protocol=Zero-shot2026.05 | 75.1 | -8.69 | |
| Gex.Target Gene=CTSK, Evaluation Protocol=Zero-shot2026.05 | 74.9 | -7.55 | |
| Gex.Target Gene=EGFR, Evaluation Protocol=Zero-shot2026.05 | 74.7 | -7.3 | |
| Gx2.Target Gene=MTOR, Evaluation Protocol=Zero-shot2026.05 | 74.5 | -7.02 | |
| Gex.Target Gene=AURKB, Evaluation Protocol=Zero-shot2026.05 | 74.4 | -7.4 | |
| Gx2.Target Gene=AKT1, Evaluation Protocol=Zero-shot2026.05 | 74.3 | -7 | |
| Gx2.Target Gene=EGFR, Evaluation Protocol=Zero-shot2026.05 | 73.8 | -6.91 | |
| Gex.Target Gene=AKT1, Evaluation Protocol=Zero-shot2026.05 | 72.8 | -7.45 | |
| Gx2.Target Gene=PIK3CA, Evaluation Protocol=Zero-shot2026.05 | 72.6 | -7.47 | |
| Gex.Target Gene=HDAC1, Evaluation Protocol=Zero-shot2026.05 | 72 | -7 | |
| Gx2.Target Gene=AURKB, Evaluation Protocol=Zero-shot2026.05 | 71.9 | -7.38 | |
| Gex.Target Gene=AKT2, Evaluation Protocol=Zero-shot2026.05 | 71.2 | -7.48 | |
| Gx2.Target Gene=AKT2, Evaluation Protocol=Zero-shot2026.05 | 70.6 | -7.39 | |
| Gx2.Target Gene=CTSK, Evaluation Protocol=Zero-shot2026.05 | 69.9 | -7.29 | |
| Gx2.Target Gene=HDAC1, Evaluation Protocol=Zero-shot2026.05 | 69.7 | -7.27 | |
| TRIO.Target Gene=SMAD3, Evaluation Protocol=Zero-shot2026.05 | 59 | -5.99 | |
| TRIO.Target Gene=TP53, Evaluation Protocol=Zero-shot2026.05 | 58.8 | -5.76 | |
| TRIO.Target Gene=AURKB, Evaluation Protocol=Zero-shot2026.05 | 55.3 | -6.49 | |
| TRIO.Target Gene=AKT1, Evaluation Protocol=Zero-shot2026.05 | 54 | -5.67 | |
| TRIO.Target Gene=EGFR, Evaluation Protocol=Zero-shot2026.05 | 54 | -6.11 | |
| TRIO.Target Gene=CTSK, Evaluation Protocol=Zero-shot2026.05 | 53.5 | -6.38 | |
| TRIO.Target Gene=MTOR, Evaluation Protocol=Zero-shot2026.05 | 52.7 | -5.91 | |
| TRIO.Target Gene=PIK3CA, Evaluation Protocol=Zero-shot2026.05 | 52.4 | -5.8 | |
| TRIO.Target Gene=HDAC1, Evaluation Protocol=Zero-shot2026.05 | 51.9 | -5.85 | |
| TRIO.Target Gene=AKT2, Evaluation Protocol=Zero-shot2026.05 | 51.5 | -5.82 |