Unconditional Protein Design on UniRef50
55.25Perplexity (PPL)ProteinOPD
Evaluation Results
| Method | Links | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ProteinOPD2026.05 | 55.25 | 54.96 | 75.68 | 74.37 | 61.72 | 13.91 | 45.7 | 69 | 74 | 62 | |
| ProDVa2026.05 | 79.42 | 2.21 | 37.58 | 58.04 | 9.38 | 18.88 | 7.81 | 36 | 5 | 2 | |
| ProGen22026.05 | 113.04 | 85.76 | 58.7 | 47.44 | 10.55 | 24.7 | 6.25 | 54 | 29 | 44 | |
| ProtGPT22026.05 | 339.57 | 59.97 | 69.17 | 64.77 | 42.58 | 17.69 | 24.61 | 59 | 48 | 33 | |
| ESM32026.05 | 353.71 | 51.21 | 72.66 | 61.3 | 27.49 | 19.68 | 20.52 | 31 | 56 | 21 | |
| Pinal2026.05 | 542.49 | 46.44 | 45.68 | 64.32 | 52.79 | 15.92 | 40.28 | 41 | 28 | 37 | |
| MoMPNN2026.05 | 748.73 | 42.5 | 65.47 | 70.19 | 50.66 | 16.78 | 35.05 | 57 | 65 | 46 | |
| ASPO2026.05 | 804.45 | 51.57 | 56.77 | 47.99 | 1.95 | 19.63 | 3.12 | 69 | 68 | 17 | |
| ProteinDT2026.05 | 1,255.16 | 50.69 | 52.25 | 42.75 | 11.37 | 24.77 | 5.82 | 39 | 36 | 29 | |
| ProLLaMA2026.05 | 1,445.8 | 55.07 | 42.95 | 40.17 | 0 | 19.4 | 0.39 | 63 | 49 | 6 | |
| ESM22026.05 | 1,467.04 | 52.75 | 60.72 | 47.52 | 5.68 | 25.7 | 0.55 | 40 | 42 | 15 | |
| Random (E)2026.05 | 1,747.35 | 59.84 | — | 26.9 | 0.39 | 23.99 | 0.78 | 44 | 3 | 1 | |
| Random (U)2026.05 | 1,765.28 | 57.13 | — | 24.02 | 0 | 24.15 | 0 | 34 | 2 | 5 |