ResearchBenchmarksScaffold-constrained molecule generation on Σ1 (Quinoline) PubChem CID 7047Scaffold-constrained molecule generation on Σ1 (Quinoline) PubChem CID 7047Follow100ValidityMOLER81.69686.44891.295.952Feb 18, 2026Evaluation resultsMethodMethodLinksValidityUniquenessNoveltyMOLER2026.0210093.2100NSGGM2026.0210098.9100GENMOL2026.0282.475.170.3