Retrosynthesis on USPTO-50k Without Reaction Type benchmark leaderboard · SOTA2 Research

Retrosynthesis on USPTO-50k Without Reaction Type

75.1Top-1 AccuracyRxnNano-0.5B(AAM)

Evaluation Results

Method	Links
RxnNano-0.5B(AAM)2026.02		75.1	90.8	93.4	96.6
RxnNano-0.5B(w/oAAM)2026.02		69.8	89	92.8	95.8
EditRetro2026.02		60.8	80.6	86	90.3
RetroDFM-R-7B2026.02		59	—	—	—
RetroExplainer2026.02		57.7	79.2	84.8	91.4
RetroKNN2026.02		57.2	78.9	86.4	92.7
R-SMILES2026.02		56.3	79.2	86.2	91
Graph2Edits2026.02		55.1	77.3	83.4	89.4
Chemformer2026.02		54.3	—	62.3	63
GraphRetro2026.02		53.7	68.3	72.2	75.5
Ualign2026.02		53.5	77.3	84.6	90.5
LocalRetro2026.02		53.4	77.5	85.9	92.4
Retroformer2026.02		53.2	71.1	76.6	82.1
Graph2SMILES (D-GCN)2026.02		52.9	66.5	70	72.9
GLN2026.02		52.5	69	75.6	83.7
RetroPrime2026.02		51.4	70.8	74	76.1
GTA2026.02		51.1	67.6	74.8	81.6
RetroXpert2026.02		50.4	61.1	62.3	63.4
ChemDual-8B2026.02		50	67.7	70.5	78.3
G2G2026.02		48.9	67.6	72.5	75.5
Augmented Transformer2026.02		48.3	—	73.4	77.4
MEGAN2026.02		48.1	70.7	78.4	86.1
Tied Transformer2026.02		47.1	67.2	73.5	78.5
DMP fusion2026.02		46.1	65.2	70.4	74.3
GET2026.02		44.9	58.8	62.4	65.9
NeuralSym2026.02		44.4	65.3	72.4	78.9
SCROP2026.02		43.7	60	65.2	68.7
AutoSynRoute2026.02		43.1	64.6	71.8	78.7
Seq2Seq2026.02		37.4	52.4	57	61.7
RetroSim2026.02		37.3	54.7	63.3	74.1