Protein Structure Generation on Foldseek AFDB clusters DFS (test) benchmark leaderboard · SOTA2 Research

Protein Structure Generation on Foldseek AFDB clusters DFS (test)

97.6DesignabilityProteína M_FS^small + Quotient-space diffusion

Evaluation Results

Method
Proteína M_FS^small + Quotient-space diffusion2026.04	97.6	274.7	277.1	2.24	6.69	20.99	1.68	1.55
FoldFlow (OT)2026.04	97.2	431.4	414.1	1.35	3.1	13.62	2.9	2.32
FoldFlow (stoc.)2026.04	97	543.6	520.4	1.21	2.09	11.59	3.69	2.71
FoldFlow (base)2026.04	96.6	601.5	566.2	1.06	1.79	9.72	3.18	3.1
Proteína M_FS^small2026.04	96	386.5	378.2	1.77	4.97	17.78	2.17	1.73
Genie22026.04	95.2	350	313.8	1.55	3.66	11.65	2.21	1.7
RFDiffusion2026.04	94.4	253.7	252.4	2.25	5.06	19.83	1.21	1.13
Proteus2026.04	94.2	225.7	226.2	2.26	5.46	16.22	1.41	1.37
Proteína M_FS^small + Quotient-space diffusion2026.04	92.6	244.5	246.3	2.24	6.68	23.47	1.43	1.28
Proteína M_FS^small2026.04	92.2	332.9	320.4	1.83	5.01	20.22	1.93	1.49
Proteína M_FS^small + Quotient-space diffusion2026.04	90.2	228	228.7	2.25	6.59	25.24	1.32	1.17
Proteína M_FS^small2026.04	89.2	306.2	290.8	1.86	4.92	21.15	1.81	1.36
FrameFlow2026.04	88.6	129.9	159.9	2.52	5.88	27	0.68	0.91
Chroma2026.04	74.8	189	184.1	2.34	4.95	18.15	1	1.08
FrameDiff2026.04	65.4	194.2	258.1	2.46	5.78	23.35	1.04	1.42
ESM32026.04	22	933.9	855.4	3.19	6.71	17.73	1.53	0.98
Proteína M_FS2026.04	19.6	85.4	21.4	2.51	5.65	27.35	0.59	0.09
Proteína M_FS^small + Quotient-space diffusion2026.04	15.6	69.9	17.6	2.57	6.4	32.14	0.41	0.11
Proteína M_FS^small2026.04	13.8	83.2	21.9	2.45	5.63	31.76	0.58	0.12
Proteína M_FS^small + AF3 alignment2026.04	3.8	229	82.4	2.18	4.3	14.28	1.35	0.36