Protein Redesign on 400 protein redesign examples monomer protein structures
21.6Success Rate (RF3)RosettaSearch
Evaluation results
| Method | Links | ||
|---|---|---|---|
| RosettaSearchInitialization=(b) LigandMPNN designs, Objective function=Cumulative2026.04 | 21.6 | — | |
| RosettaSearchInitialization=(b) LigandMPNN designs, Objective function=Multi-obj. (ss-pLDDT, TM-score, Cα-RMSD)2026.04 | 20.5 | 5.3 | |
| RosettaSearchInitialization=(b) LigandMPNN designs, Objective function=Single obj. (ss-pLDDT)2026.04 | 18.4 | 5 | |
| RosettaSearchInitialization=(b) LigandMPNN designs, Objective function=Multi-obj. (ss-pLDDT, TM-score)2026.04 | 17.1 | 6.7 | |
| RosettaSearchInitialization=(a) Native monomer sequences, Objective function=Cumulative2026.04 | 10.1 | — | |
| RosettaSearchInitialization=(a) Native monomer sequences, Objective function=Multi-obj. (ss-pLDDT, TM-score)2026.04 | 9.1 | 4.7 | |
| RosettaSearchInitialization=(a) Native monomer sequences, Objective function=Multi-obj. (ss-pLDDT, TM-score, Cα-RMSD)2026.04 | 8.4 | 4.3 | |
| LigandMPNN designsCategory=Baseline success rates of various starting sequences2026.04 | 7.9 | 3.1 | |
| Random mutations baselineInitialization=LigandMPNN designed sequences2026.04 | 7.9 | 3.1 | |
| RosettaSearchInitialization=(a) Native monomer sequences, Objective function=Single obj. (ss-pLDDT)2026.04 | 7.5 | 4.2 | |
| Native monomer sequencesCategory=Baseline success rates of various starting sequences2026.04 | 7 | 2.4 | |
| Random protein sequencesCategory=Baseline success rates of various starting sequences2026.04 | 0 | 0 |