Protein-protein binding affinity prediction on PPB-affinity filtered (test)
0.496Pearson rCombined (ProtT5-PAD + Boltz-2-PPI)
Evaluation results
| Method | Links | |||
|---|---|---|---|---|
| Combined (ProtT5-PAD + Boltz-2-PPI)type=Combined model, sequence_backbone=ProtT5-PAD, structural_backbone=Boltz-2-PPI2025.12 | 0.496 | 0.515 | 1.326 | |
| Combined (ESM2-650M-SC + Boltz-2-PPI)type=Combined model, sequence_backbone=ESM2-650M-SC, structural_backbone=Boltz-2-PPI2025.12 | 0.487 | 0.483 | 1.367 | |
| ProtT5-PADtype=Sequence baseline2025.12 | 0.48 | 0.51 | 1.42 | |
| ESM2-650M-SCtype=Sequence baseline2025.12 | 0.47 | 0.48 | 1.74 | |
| Boltz-2-PPItraining_mode=fine-tuned, input=structure only2025.12 | 0.338 | 0.357 | 1.362 |