Mutation Fitness Prediction on ProteinGym substitution benchmark (217 proteins) (fold 4 test)
89.74AUROCTriFit
Evaluation Results
| Method | Links | ||||||
|---|---|---|---|---|---|---|---|
| TriFitModel=TriFit2026.04 | 89.74 | 90.88 | 80.7 | 80.21 | 80.08 | 80.39 | |
| KermutModel=Kermut2026.04 | 86.44 | 86.97 | 74.32 | 73.24 | 77.44 | 74.32 | |
| ProteinNPTModel=ProteinNPT2026.04 | 84.39 | 85.37 | 73.03 | 71.93 | 76 | 73.03 | |
| Emb + MSA-TEmbedding=MSA Transformer2026.04 | 83.34 | 84.78 | 72.17 | 71.05 | 75.06 | 72.16 | |
| Emb + ESM-1vEmbedding=ESM-1v2026.04 | 80.62 | 81.7 | 70.07 | 68.92 | 72.81 | 70.06 | |
| OHE + TranceptEVEAugmentation=TranceptEVE2026.04 | 77.44 | 80.51 | 67.99 | 66.8 | 70.54 | 67.98 | |
| OHE + MSA-TAugmentation=MSA Transformer2026.04 | 76.44 | 79.68 | 67.34 | 66.12 | 69.67 | 67.34 | |
| OHE + ESM-1vAugmentation=ESM-1v2026.04 | 75.81 | 78.38 | 66.92 | 65.69 | 69.22 | 66.91 | |
| OHE (no aug.)Augmentation=None2026.04 | 63.87 | 69.9 | 59.01 | 57.6 | 60.34 | 59.01 |