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Gene deletion fitness prediction on Yeast Digenic Deletion Fitness (10-fold cross-validation)

0.377Mean R2GNN + Ldistance
0.183560.233780.2840.33422May 5, 2026

Evaluation results

MethodLinks
GNN + LdistanceModel Architecture=GNN, Embedding Type=Pre-trained box embeddings, Loss Function=Distance-based semantic loss2026.050.3770.046
GNN + LoverlapModel Architecture=GNN, Embedding Type=Pre-trained box embeddings, Loss Function=Overlap semantic loss2026.050.3680.038
GNN with prior box embeddingsModel Architecture=GNN, Embedding Type=Pre-trained box embeddings2026.050.360.043
GNN with subClassOf-links in KGModel Architecture=GNN, Embedding Type=Task-specific shallow embeddings, Hierarchy=Introduced as links in KG2026.050.350.049
GNN without box embeddingsModel Architecture=GNN, Embedding Type=Task-specific shallow embeddings (non-box form)2026.050.3480.05
Instantiations + LightGBMModel Architecture=LightGBM, Embedding Type=Instantiations, KG Representation=Sparse feature matrix2026.050.2110.022
ComplEx + LightGBMModel Architecture=LightGBM, Embedding Type=ComplEx, KG Representation=Sparse feature matrix2026.050.1910.039