Fixed-backbone Sequence Design on 8 PDBs
570RMSD (mÅ)ProteinMPNN
Evaluation results
| Method | Links | |||||
|---|---|---|---|---|---|---|
| ProteinMPNN2026.03 | 570 | — | — | — | 93.8 | |
| Gemini 2.5 FlashFramework=Agent Rosetta, Aggregation=best-of-8 median2026.03 | 571 | 0.13 | 91 | 93 | 92.7 | |
| Qwen3 InstructFramework=Agent Rosetta, Reasoning=CoT, Aggregation=best-of-8 median2026.03 | 606 | 0.03 | 86 | 70 | 92.3 | |
| Sonnet 4.5Framework=Agent Rosetta, Aggregation=best-of-8 median2026.03 | 619 | 0.63 | 93 | 64 | 92.1 | |
| GPT-5Framework=Agent Rosetta, Aggregation=best-of-8 median2026.03 | 639 | 0.33 | 92 | 69 | 92 | |
| naïve baseline2026.03 | 985 | — | 100 | — | 91.5 | |
| human baselineProtocol=one-shot2026.03 | 985 | — | 100 | — | 89.8 | |
| human baselineProtocol=staged2026.03 | 1,128 | — | 100 | — | 88.6 |