Fitness Prediction on ProteinGym
0.78Spearman Correlation (GFP Stability)Physio-DPO
Evaluation results
| Method | Links | |||||||
|---|---|---|---|---|---|---|---|---|
| Physio-DPOBackbone=ProGen2-XL, Model Size (Parameters)=6.4B, Evaluation Protocol (Zero-shot)=true2026.01 | 0.78 | 0.63 | 0.75 | 0.76 | 0.7 | 0.72 | — | |
| DPO (Standard)Backbone=ProGen2-XL, Model Size (Parameters)=6.4B, Evaluation Protocol (Zero-shot)=true2026.01 | 0.71 | 0.59 | 0.73 | 0.7 | 0.61 | 0.67 | — | |
| SFTBackbone=ProGen2-XL, Model Size (Parameters)=6.4B, Evaluation Protocol (Zero-shot)=true2026.01 | 0.66 | 0.55 | 0.7 | 0.67 | 0.56 | 0.63 | — | |
| TranceptionEvaluation Protocol (Zero-shot)=true2026.01 | 0.65 | 0.68 | 0.72 | 0.69 | 0.48 | 0.64 | — | |
| ProGen2-XL (Base)Backbone=ProGen2-XL, Model Size (Parameters)=6.4B, Evaluation Protocol (Zero-shot)=true2026.01 | 0.64 | 0.56 | 0.71 | 0.65 | 0.53 | 0.62 | — | |
| ESM-2 (3B)Backbone=ESM-2, Model Size (Parameters)=3B, Evaluation Protocol (Zero-shot)=true2026.01 | 0.62 | 0.55 | 0.7 | 0.63 | 0.51 | 0.6 | — | |
| PPO (RLHF)Backbone=ProGen2-XL, Model Size (Parameters)=6.4B, Evaluation Protocol (Zero-shot)=true2026.01 | 0.62 | 0.53 | 0.65 | 0.61 | 0.54 | 0.59 | — |