ResearchBenchmarksBinding Affinity Prediction on Koenig (Heavy chain mutation)Binding Affinity Prediction on Koenig (Heavy chain mutation)Follow0.456Spearman CorrelationCoSiNE-0.111840.035580.1830.33042Feb 21, 2026Evaluation resultsMethodMethodLinksSpearman CorrelationCoSiNE2026.020.456DASM2026.020.415ESM2parameters=150Mparameters=150M2026.020.112PROGEN2size=SMALLsize=SMALL2026.020.098PROGEN2size=MEDIUMsize=MEDIUM2026.020.085ESM2parameters=650Mparameters=650M2026.020.063ABLANG-22026.02-0.09