Binding Affinity Prediction on CASF 2016 (test)
1.159RMSEPhi-former (ours)
Evaluation results
| Method | Links | ||
|---|---|---|---|
| Phi-former (ours)pre-training=pairwise hierarchical2026.02 | 1.159 | 0.846 | |
| SS-GNN2026.02 | 1.181 | 0.853 | |
| Literature SOTA2026.06 | 1.181 | — | |
| BioMatrix-1.7B2026.06 | 1.268 | — | |
| BioMatrix-4B2026.06 | 1.268 | — | |
| KDeep2026.02 | 1.27 | 0.82 | |
| OnionNet2026.02 | 1.278 | 0.816 | |
| Mol-PSI2026.02 | 1.278 | 0.844 | |
| IGN2026.02 | 1.291 | 0.811 | |
| SIGN2026.02 | 1.316 | 0.797 | |
| ESM-1bfeature extractor with frozen weights=true2026.06 | 1.368 | — | |
| CNN2026.06 | 1.376 | — | |
| Phi-former (no pre-train)pre-training=none2026.02 | 1.379 | 0.771 | |
| Pre-train baselineBackbone=Uni-Mol2026.02 | 1.418 | 0.758 | |
| ResNet2026.06 | 1.441 | — | |
| Transformer2026.06 | 1.455 | — | |
| LSTM2026.06 | 1.457 | — | |
| ProtBertfeature extractor with frozen weights=true2026.06 | 1.457 | — | |
| ESM-1bfeature extractor with frozen weights=false2026.06 | 1.559 | — | |
| GraphDTA2026.02 | 1.562 | 0.697 | |
| ProtBertfeature extractor with frozen weights=false2026.06 | 1.562 | — | |
| ΔVinaRF202026.02 | — | 0.816 |