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Binary Protein-Protein Interaction Prediction on SHS27k Binding (Random)

81.27Micro F1 ScorePIPR+
62.91467.679572.44577.2105May 11, 2026

Evaluation results

MethodLinks
PIPR+L3-PPI framework=integrated2026.0581.27
GearNet+L3-PPI framework=integrated2026.0580.79
GNN-PPI+L3-PPI framework=integrated2026.0580.02
ESM2-650M+L3-PPI framework=integrated2026.0579.62
PIPRL3-PPI framework=excluded2026.0579.53
GNN-PPIL3-PPI framework=excluded2026.0577.78
ProstT5+L3-PPI framework=integrated2026.0577.21
MLPL3-PPI framework=excluded2026.0576.54
MLP+L3-PPI framework=integrated2026.0575.43
Saprot+L3-PPI framework=integrated2026.0573.33
DPPI+L3-PPI framework=integrated2026.0569.94
DNN-PPI+L3-PPI framework=integrated2026.0567.71
DPPIL3-PPI framework=excluded2026.0565.17
DNN-PPIL3-PPI framework=excluded2026.0563.62