Scalable Training of Spatially Grounded 2D Vision-Language Models for Radiology

We study how to train visually grounded vision-language models (VLMs) for radiology without manual spatial annotations. We introduce RefRad2D, a large-scale bilingual (German/English) dataset of 1.2M CT and MR image-text pairs derived from clinical practice, with task-specific VQA and spatial grounding subsets generated automatically via LLM-based curation and automated segmentation. Trained on this data, our model RadGrounder jointly performs report generation, visual question answering, and spatial grounding via bounding-box detection or segmentation. On external VQA benchmarks (Slake, VQA-RAD), RadGrounder achieves competitive results with specialized medical VLMs. Adding our clinical data to the training mixture improves open-ended VQA over fine-tuning on the downstream datasets alone, showing the transferability of our dataset. Crucially, adding grounding supervision does not degrade language quality, enabling spatially verifiable outputs at no cost to VQA performance.

Yusuf Salcan, Simon Ging, Robin Tibor Schirrmeister, Philipp Arnold, Elmar Kotter, Behzad Bozorgtabar, Thomas Brox (1) __INSTITUTION_7__ Computer Vision Group, University of Freiburg, Germany, (2) Adaptive & Agentic AI __INSTITUTION_9__ Lab, Aarhus University, Denmark, (3) Department of Radiology, Medical Center -- University of Freiburg, Germany, (4) CRIION-AI Lab, Freiburg, Germany) · 2026