SAFE-Diff: Scale-Aware Attention and Feature-Dispersive Diffusion with Uncertainty Estimation for Contrast-Enhanced Breast MRI Synthesis

Synthesizing high fidelity contrast enhanced MRI is clinically valuable for safer and more efficient breast cancer screening, yet remains challenging due to complex lesion textures and heterogeneous enhancement patterns.

Tianyu Zhang, Xinglong Liang, Jarek van Dijk, Luyi Han, Chunyao Lu, Antonio Portaluri, Xinghe Xie, Yaofei Duan, Nika Rasoolzadeh, Xin Wang, Yuan Gao, Muzhen He, Yue Sun, Jonas Teuwen, Tao Tan, Ritse Mann · 2026