Multi-Level CLS Token Fusion for Contrastive Learning in Endoscopy Image Classification

We present a unified vision-language framework tailored for ENT endoscopy image analysis that simultaneously tackles three clinically-relevant tasks: image classification, image-to-image retrieval, and text-to-image retrieval. Unlike conventional CNN-based pipelines that struggle to capture cross-modal semantics, our approach leverages the CLIP ViT-B/16 backbone and enhances it through Low-Rank Adaptation, multi-level CLS token aggregation, and spherical feature interpolation. These components collectively enable efficient fine-tuning on limited medical data while improving representation diversity and semantic alignment across modalities. To bridge the gap between visual inputs and textual diagnostic context, we introduce class-specific natural language prompts that guide the image encoder through a joint training objective combining supervised classification with contrastive learning. We validated our framework through participation in the ACM MM'25 ENTRep Grand Challenge, achieving 95% accuracy and F1-score in classification, Recall@1 of 0.93 and 0.92 for image-to-image and text-to-image retrieval respectively, and MRR scores of 0.97 and 0.96. Ablation studies demonstrated the incremental benefits of each architectural component, validating the effectiveness of our design for robust multimodal medical understanding in low-resource clinical settings.

Y Hop Nguyen, Doan Anh Phan Huu, Trung Thai Tran, Nhat Nam Mai, Van Toi Giap, Thao Thi Phuong Dao, Trung-Nghia Le · 2025