Superpixel Boundary Correction for Weakly-Supervised Semantic Segmentation on Histopathology Images

With the rapid advancement of deep learning, computational pathology has made significant progress in cancer diagnosis and subtyping. Tissue segmentation is a core challenge, essential for prognosis and treatment decisions. Weakly supervised semantic segmentation (WSSS) reduces the annotation requirement by using image-level labels instead of pixel-level ones. However, Class Activation Map (CAM)-based methods still suffer from low spatial resolution and unclear boundaries. To address these issues, we propose a multi-level superpixel correction algorithm that refines CAM boundaries using superpixel clustering and floodfill. Experimental results show that our method achieves great performance on breast cancer segmentation dataset with mIoU of 71.08%, significantly improving tumor microenvironment boundary delineation.

Hongyi Wu, Hong Zhang · 2025