Permutation, Multiscale and Modified Multiscale Entropies a Natural Complexity for Low-High Infection Level Intracellular Viral Reaction Kinetics

Viral infectious diseases, such as HIV virus growth, cause an important health concern. Study of intracellular viral processes can provide us to develop drug and understanding the drug dose to decrease the HIV virus in during growth. Kinetics Monte Carlo simulation has been done for solving Master equation about dynamics of intracellular viral reaction kinetics. Scaling relationship between equilibrium time and initial population of template has been found as power low, , where N , are the number of initial population of template species , equilibrium time, a = 163.1 , b = -0.1429 respectively. Stochastic dynamics shows that increasing initial population of template decreases the time of equilibrium. Entropy generation has been considered in low, intermediate and high infection level of intracellular viral kinetics reaction in during dynamical process. Permutation, multi scaling and modified multiscaling entropies have been calculated for three kinds of species in intracellular reaction dynamics, genome, structural protein, and template. Our result shows that presence of noise in dynamical process of intracellular reaction will change order of permutation entropy for the mentioned of three species. In addition to multiscaling entropy is computed for mentioned model and it has the following order: template > structural protein> genome. Dependency of permutation entropy result to permutation order becomes small in high infection level in intracellular viral kinetics dynamics. At short time scale in intracellular reaction dynamics, convergency of permutation entropy occurs with medium permutation order value. In the big time scale of intracellular dynamics, permutation entropy scale with permutation order n as a scaling relation .

Fariborz Taherkhani, Farid Taherkhani · 2016