Algorithm for Predicting Protein Secondary Structure

Predicting protein structure from amino acid sequence is one of the most important unsolved problems of molecular biology and biophysics.Not only would a successful prediction algorithm be a tremendous advance in the understanding of the biochemical mechanisms of proteins, but, since such an algorithm could conceivably be used to design proteins to carry out specific functions.Prediction of the secondary structure of a protein (alpha-helix, beta-sheet, coil) is an important step towards elucidating its three dimensional structure as well as its function. In this research, we use different Hidden Markov models for protein secondary structure prediction. In this paper we have proposed an algorithm for predicting protein secondary structure. We have used Hidden Markov model with sliding window for secondary structure prediction.The secondary structure has three regular forms, for each secondary structural element we are using one Hidden Markov Model.

K. K Senapati, G. Sahoo, D. Bhaumik · 2010