Dynamic stability of spindles controlled by molecular motor kinetics

We analyze the role of the force-dependent kinetics of motor proteins in the stability of antiparallel arrays of polar filaments, such as those in the mitotic spindle. We determine the possible stable structures and show that there exists an instability associated to the collective behavior of motors that leads to the collapse of the spindle. Our analysis provides a general framework to understand several experimental observations in eukaryotic cell division.

Otger Campas, Jaume Casademunt, Ignacio Pagonabarraga · 2006