# Sequence-structure co-design on Protein-peptide binding receptors (test)

Source: [Sequence-structure co-design on Protein-peptide binding receptors (test)](<https://www.sota2.com/research/sota/sequence-structure-co-design-on-protein-peptide-binding-receptors-test>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-02-26T05:41:13.410Z

Evaluation of models performing sequence-structure co-design on the test split of the Protein-peptide binding receptors dataset, assessed using metrics like diversity, constraint satisfaction, binding energy (ΔG), and success rate.

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Sequence-structure co-design |
| Dataset (including any stated split) | Protein-peptide binding receptors (test) |
| Metric | Diversity |
| Unit | PERCENT |
| Direction | Higher is better |
| Results loaded | 3 of 3 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [Diversity](<https://www.sota2.com/research/sota/sequence-structure-co-design-on-protein-peptide-binding-receptors-test.md?metric=Diversity>): Higher is better; unit: PERCENT.

- [Constraint Satisfaction](<https://www.sota2.com/research/sota/sequence-structure-co-design-on-protein-peptide-binding-receptors-test.md?metric=Constraint%20Satisfaction>): Higher is better; unit: PERCENT.

- [Binding Energy (ΔG)](<https://www.sota2.com/research/sota/sequence-structure-co-design-on-protein-peptide-binding-receptors-test.md?metric=Binding%20Energy%20(%CE%94G)>): Lower is better; unit: SCALAR.

- [Success Rate](<https://www.sota2.com/research/sota/sequence-structure-co-design-on-protein-peptide-binding-receptors-test.md?metric=Success%20Rate>): Higher is better; unit: PERCENT.

## Recorded results

| Method | Diversity | Result date | Report paper |
| --- | --- | --- | --- |
| PepGLAD | 50.6 | Not recorded | 68fa5f6e1e209131ce9e9d2f |
| RFDiffusion | 25.9 | Not recorded | 68fa5f6e1e209131ce9e9d2f |
| AnchorExtension | 24.5 | Not recorded | 68fa5f6e1e209131ce9e9d2f |

### PepGLAD

Diversity: 50.6. Result ID: 698bc7577a967eddb7714853.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9d2f.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9d2f.md>)

[Implementation](<https://github.com/THUNLP-MT/PepGLAD>)

Recorded evaluation configuration: {"Time":"3s"}. This record does not assert independent reproduction.

### RFDiffusion

Diversity: 25.9. Result ID: 698bc7577a967eddb7714852.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9d2f.md>)

Recorded evaluation configuration: {"Time":"61s"}. This record does not assert independent reproduction.

### AnchorExtension

Diversity: 24.5. Result ID: 698bc7577a967eddb7714851.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9d2f.md>)

Recorded evaluation configuration: {"Time":"735s","Number of candidates per receptor":"10"}. This record does not assert independent reproduction.

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