# Retrosynthesis planning on USPTO Easy Source: [Retrosynthesis planning on USPTO Easy]() Collection index: [llms.txt]() Data updated: 2026-05-12T10:51:49.890Z Evaluation of models performing retrosynthesis planning specifically on the USPTO Easy dataset, measured by Solve Rate (%). A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. | Scope | Recorded value | | --- | --- | | Task | Retrosynthesis planning | | Dataset (including any stated split) | USPTO Easy | | Metric | Solve Rate | | Unit | PERCENT | | Direction | Higher is better | | Results loaded | 30 of 30 | | Coverage | All results currently returned for this benchmark | Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol. ## Metrics - [Solve Rate](): Higher is better; unit: PERCENT. ## Recorded results | Method | Solve Rate | Result date | Report paper | | --- | --- | --- | --- | | LLM-Syn-Planner | 100 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM-Syn-Planner | 100 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM-Syn-Planner | 99.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM-Syn-Planner | 99.5 | Not recorded | 68fa4a371e209131ce93cac1 | | RootAligned | 99 | Not recorded | 68fa4a371e209131ce93cac1 | | RootAligned | 99 | Not recorded | 68fa4a371e209131ce93cac1 | | RootAligned | 99 | Not recorded | 68fa4a371e209131ce93cac1 | | RootAligned | 98.5 | Not recorded | 68fa4a371e209131ce93cac1 | | RootAligned | 98.5 | Not recorded | 68fa4a371e209131ce93cac1 | | RootAligned | 98 | Not recorded | 68fa4a371e209131ce93cac1 | | LocalRetro | 98 | Not recorded | 68fa4a371e209131ce93cac1 | | Graph2Edits | 97.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LocalRetro | 97.5 | Not recorded | 68fa4a371e209131ce93cac1 | | Graph2Edits | 96.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LocalRetro | 95.5 | Not recorded | 68fa4a371e209131ce93cac1 | | Graph2Edits | 95.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LocalRetro | 95.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LocalRetro | 94.5 | Not recorded | 68fa4a371e209131ce93cac1 | | Graph2Edits | 93.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM-Syn-Planner | 93 | Not recorded | 68fa4a371e209131ce93cac1 | | LocalRetro | 92.5 | Not recorded | 68fa4a371e209131ce93cac1 | | Graph2Edits | 92 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM-Syn-Planner | 91 | Not recorded | 68fa4a371e209131ce93cac1 | | Graph2Edits | 90 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM | 75.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM | 75.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM | 69 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM | 68.5 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM | 56 | Not recorded | 68fa4a371e209131ce93cac1 | | LLM | 54.5 | Not recorded | 68fa4a371e209131ce93cac1 | ### LLM-Syn-Planner Solve Rate: 100. Result ID: 6a03063a47f34ce924e69ce6. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"GPT-4o","N":"500"}. This record does not assert independent reproduction. ### LLM-Syn-Planner Solve Rate: 100. Result ID: 6a03063a47f34ce924e69ce9. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"DeepSeek-V3","N":"500"}. This record does not assert independent reproduction. ### LLM-Syn-Planner Solve Rate: 99.5. Result ID: 6a03063a47f34ce924e69ce5. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"GPT-4o","N":"300"}. This record does not assert independent reproduction. ### LLM-Syn-Planner Solve Rate: 99.5. Result ID: 6a03063a47f34ce924e69ce8. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"DeepSeek-V3","N":"300"}. This record does not assert independent reproduction. ### RootAligned Solve Rate: 99. Result ID: 6a03063a47f34ce924e69cd8. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"100"}. This record does not assert independent reproduction. ### RootAligned Solve Rate: 99. Result ID: 6a03063a47f34ce924e69cd9. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"300"}. This record does not assert independent reproduction. ### RootAligned Solve Rate: 99. Result ID: 6a03063a47f34ce924e69cda. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"500"}. This record does not assert independent reproduction. ### RootAligned Solve Rate: 98.5. Result ID: 6a03063a47f34ce924e69cd0. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"300"}. This record does not assert independent reproduction. ### RootAligned Solve Rate: 98.5. Result ID: 6a03063a47f34ce924e69cd1. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"500"}. This record does not assert independent reproduction. ### RootAligned Solve Rate: 98. Result ID: 6a03063a47f34ce924e69ccf. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"100"}. This record does not assert independent reproduction. ### LocalRetro Solve Rate: 98. Result ID: 6a03063a47f34ce924e69cdd. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"500"}. This record does not assert independent reproduction. ### Graph2Edits Solve Rate: 97.5. Result ID: 6a03063a47f34ce924e69cd7. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"500"}. This record does not assert independent reproduction. ### LocalRetro Solve Rate: 97.5. Result ID: 6a03063a47f34ce924e69cdc. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"300"}. This record does not assert independent reproduction. ### Graph2Edits Solve Rate: 96.5. Result ID: 6a03063a47f34ce924e69cce. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"500"}. This record does not assert independent reproduction. ### LocalRetro Solve Rate: 95.5. Result ID: 6a03063a47f34ce924e69cd4. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"500"}. This record does not assert independent reproduction. ### Graph2Edits Solve Rate: 95.5. Result ID: 6a03063a47f34ce924e69cd6. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"300"}. This record does not assert independent reproduction. ### LocalRetro Solve Rate: 95.5. Result ID: 6a03063a47f34ce924e69cdb. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"100"}. This record does not assert independent reproduction. ### LocalRetro Solve Rate: 94.5. Result ID: 6a03063a47f34ce924e69cd3. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"300"}. This record does not assert independent reproduction. ### Graph2Edits Solve Rate: 93.5. Result ID: 6a03063a47f34ce924e69ccd. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"300"}. This record does not assert independent reproduction. ### LLM-Syn-Planner Solve Rate: 93. Result ID: 6a03063a47f34ce924e69ce7. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"DeepSeek-V3","N":"100"}. This record does not assert independent reproduction. ### LocalRetro Solve Rate: 92.5. Result ID: 6a03063a47f34ce924e69cd2. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"100"}. This record does not assert independent reproduction. ### Graph2Edits Solve Rate: 92. Result ID: 6a03063a47f34ce924e69cd5. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"100"}. This record does not assert independent reproduction. ### LLM-Syn-Planner Solve Rate: 91. Result ID: 6a03063a47f34ce924e69ce4. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"GPT-4o","N":"100"}. This record does not assert independent reproduction. ### Graph2Edits Solve Rate: 90. Result ID: 6a03063a47f34ce924e69ccc. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"100"}. This record does not assert independent reproduction. ### LLM Solve Rate: 75.5. Result ID: 6a03063a47f34ce924e69ce0. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"500"}. This record does not assert independent reproduction. ### LLM Solve Rate: 75.5. Result ID: 6a03063a47f34ce924e69ce3. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"500"}. This record does not assert independent reproduction. ### LLM Solve Rate: 69. Result ID: 6a03063a47f34ce924e69ce2. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"300"}. This record does not assert independent reproduction. ### LLM Solve Rate: 68.5. Result ID: 6a03063a47f34ce924e69cdf. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"300"}. This record does not assert independent reproduction. ### LLM Solve Rate: 56. Result ID: 6a03063a47f34ce924e69ce1. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"Retro\*","N":"100"}. This record does not assert independent reproduction. ### LLM Solve Rate: 54.5. Result ID: 6a03063a47f34ce924e69cde. [Reporting paper]() Recorded evaluation configuration: {"Search Strategy":"MCTS","N":"100"}. This record does not assert independent reproduction. 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