Protein Design on unseen ligands zero-shot
88.2ipTMInstructPro-3B
Evaluation Results
| Method | Links | |||||
|---|---|---|---|---|---|---|
| InstructPro-3BParameters=3B, Setting=zero-shot2025.06 | 88.2 | -6.797 | 2.439 | 90.207 | 67.542 | |
| InstructPro-1BParameters=1B, Setting=zero-shot2025.06 | 86.9 | -6.713 | 2.638 | 90.518 | 68.802 | |
| AlphaFold3+LigandMPNNSetting=zero-shot2025.06 | 86.8 | -6.325 | 2.923 | 89.862 | 67.291 | |
| PinalParameters=1.2B, Setting=zero-shot2025.06 | 81.4 | -6.071 | 3.247 | 87.157 | 63.347 | |
| ESM3Parameters=1.4B, Setting=zero-shot2025.06 | 77.4 | -5.43 | 5.757 | 86.857 | 77.529 | |
| ProGen2Parameters=764M, Setting=zero-shot2025.06 | 68.6 | -5.697 | 9.079 | 69.176 | 50.95 |