# Peptide-HLA binding prediction on Peptide-HLA Source: [Peptide-HLA binding prediction on Peptide-HLA]() Collection index: [llms.txt]() Data updated: 2026-05-11T09:50:27.698Z Evaluation of models on predicting Peptide-HLA binding affinity or interaction using the Peptide-HLA dataset, measured by ROC-AUC. A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. | Scope | Recorded value | | --- | --- | | Task | Peptide-HLA binding prediction | | Dataset (including any stated split) | Peptide-HLA | | Metric | ROC-AUC | | Unit | SCALAR | | Direction | Higher is better | | Results loaded | 31 of 31 | | Coverage | All results currently returned for this benchmark | Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol. ## Metrics - [ROC-AUC](): Higher is better; unit: SCALAR. ## Recorded results | Method | ROC-AUC | Result date | Report paper | | --- | --- | --- | --- | | Masked-pos | 0.892 | Not recorded | 6a0162b1dbc836b87d823279 | | ProteinBERT2-150M masked-pos | 0.891 | Not recorded | 6a0162b1dbc836b87d823279 | | Masked-pos | 0.884 | Not recorded | 6a0162b1dbc836b87d823279 | | MLM-only | 0.882 | Not recorded | 6a0162b1dbc836b87d823279 | | All-pos MLM+JEPA | 0.878 | Not recorded | 6a0162b1dbc836b87d823279 | | Baseline | 0.876 | Not recorded | 6a0162b1dbc836b87d823279 | | MLM-only | 0.874 | Not recorded | 6a0162b1dbc836b87d823279 | | Masked-pos | 0.874 | Not recorded | 6a0162b1dbc836b87d823279 | | MLM-only | 0.872 | Not recorded | 6a0162b1dbc836b87d823279 | | Masked-pos (run 1) | 0.869 | Not recorded | 6a0162b1dbc836b87d823279 | | Masked-pos (run 2) | 0.868 | Not recorded | 6a0162b1dbc836b87d823279 | | Baseline | 0.864 | Not recorded | 6a0162b1dbc836b87d823279 | | MLM-only | 0.864 | Not recorded | 6a0162b1dbc836b87d823279 | | Masked-pos (SGDm) | 0.86 | Not recorded | 6a0162b1dbc836b87d823279 | | Baseline | 0.859 | Not recorded | 6a0162b1dbc836b87d823279 | | All-pos MLM+JEPA | 0.854 | Not recorded | 6a0162b1dbc836b87d823279 | | Masked-pos (AdamW) | 0.852 | Not recorded | 6a0162b1dbc836b87d823279 | | EMA (4h) | 0.849 | Not recorded | 6a0162b1dbc836b87d823279 | | All-pos MLM+JEPA | 0.845 | Not recorded | 6a0162b1dbc836b87d823279 | | MLM+JEPA @90k | 0.841 | Not recorded | 6a0162b1dbc836b87d823279 | | All-pos MLM+JEPA | 0.829 | Not recorded | 6a0162b1dbc836b87d823279 | | ESM2-150M rand-init MLM-only | 0.816 | Not recorded | 6a0162b1dbc836b87d823279 | | Baseline | 0.794 | Not recorded | 6a0162b1dbc836b87d823279 | | MLM-only | 0.794 | Not recorded | 6a0162b1dbc836b87d823279 | | Baseline | 0.793 | Not recorded | 6a0162b1dbc836b87d823279 | | JEPA-only | 0.762 | Not recorded | 6a0162b1dbc836b87d823279 | | All-pos MLM+JEPA | 0.734 | Not recorded | 6a0162b1dbc836b87d823279 | | JEPA-only | 0.702 | Not recorded | 6a0162b1dbc836b87d823279 | | JEPA-only | 0.696 | Not recorded | 6a0162b1dbc836b87d823279 | | JEPA-only | 0.643 | Not recorded | 6a0162b1dbc836b87d823279 | | JEPA-only | 0.638 | Not recorded | 6a0162b1dbc836b87d823279 | ### Masked-pos ROC-AUC: 0.892. Result ID: 6a01a66247f34ce924e3f7ea. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"Rand-Init-35M"}. This record does not assert independent reproduction. ### ProteinBERT2-150M masked-pos ROC-AUC: 0.891. Result ID: 6a01a66247f34ce924e3f7f1. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"Not specified"}. This record does not assert independent reproduction. ### Masked-pos ROC-AUC: 0.884. Result ID: 6a01a66247f34ce924e3f7e5. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"AMPLIFY-120M"}. This record does not assert independent reproduction. ### MLM-only ROC-AUC: 0.882. Result ID: 6a01a66247f34ce924e3f7e2. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"AMPLIFY-120M"}. This record does not assert independent reproduction. ### All-pos MLM+JEPA ROC-AUC: 0.878. Result ID: 6a01a66247f34ce924e3f7de. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-150M"}. This record does not assert independent reproduction. ### Baseline ROC-AUC: 0.876. Result ID: 6a01a66247f34ce924e3f7e1. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"AMPLIFY-120M"}. This record does not assert independent reproduction. ### MLM-only ROC-AUC: 0.874. Result ID: 6a01a66247f34ce924e3f7e7. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"Rand-Init-35M"}. This record does not assert independent reproduction. ### Masked-pos ROC-AUC: 0.874. Result ID: 6a01a66247f34ce924e3f7ef. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ProteinBERT2-35M"}. This record does not assert independent reproduction. ### MLM-only ROC-AUC: 0.872. Result ID: 6a01a66247f34ce924e3f7dc. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"ESM2-150M"}. This record does not assert independent reproduction. ### Masked-pos (run 1) ROC-AUC: 0.869. Result ID: 6a01a66247f34ce924e3f7df. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-150M"}. This record does not assert independent reproduction. ### Masked-pos (run 2) ROC-AUC: 0.868. Result ID: 6a01a66247f34ce924e3f7e0. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-150M"}. This record does not assert independent reproduction. ### Baseline ROC-AUC: 0.864. Result ID: 6a01a66247f34ce924e3f7d5. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"ESM2-35M"}. This record does not assert independent reproduction. ### MLM-only ROC-AUC: 0.864. Result ID: 6a01a66247f34ce924e3f7d6. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"ESM2-35M"}. This record does not assert independent reproduction. ### Masked-pos (SGDm) ROC-AUC: 0.86. Result ID: 6a01a66247f34ce924e3f7da. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-35M"}. This record does not assert independent reproduction. ### Baseline ROC-AUC: 0.859. Result ID: 6a01a66247f34ce924e3f7db. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"ESM2-150M"}. This record does not assert independent reproduction. ### All-pos MLM+JEPA ROC-AUC: 0.854. Result ID: 6a01a66247f34ce924e3f7d8. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-35M"}. This record does not assert independent reproduction. ### Masked-pos (AdamW) ROC-AUC: 0.852. Result ID: 6a01a66247f34ce924e3f7d9. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-35M"}. This record does not assert independent reproduction. ### EMA (4h) ROC-AUC: 0.849. Result ID: 6a01a66247f34ce924e3f7f3. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"ESM2-150M"}. This record does not assert independent reproduction. ### All-pos MLM+JEPA ROC-AUC: 0.845. Result ID: 6a01a66247f34ce924e3f7e4. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"AMPLIFY-120M"}. This record does not assert independent reproduction. ### MLM+JEPA @90k ROC-AUC: 0.841. Result ID: 6a01a66247f34ce924e3f7f0. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"Not specified"}. This record does not assert independent reproduction. ### All-pos MLM+JEPA ROC-AUC: 0.829. Result ID: 6a01a66247f34ce924e3f7ee. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ProteinBERT2-35M"}. This record does not assert independent reproduction. ### ESM2-150M rand-init MLM-only ROC-AUC: 0.816. Result ID: 6a01a66247f34ce924e3f7f2. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"Not specified"}. This record does not assert independent reproduction. ### Baseline ROC-AUC: 0.794. Result ID: 6a01a66247f34ce924e3f7e6. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"Rand-Init-35M"}. This record does not assert independent reproduction. ### MLM-only ROC-AUC: 0.794. Result ID: 6a01a66247f34ce924e3f7ec. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"ProteinBERT2-35M"}. This record does not assert independent reproduction. ### Baseline ROC-AUC: 0.793. Result ID: 6a01a66247f34ce924e3f7eb. [Reporting paper]() Recorded evaluation configuration: {"Backbone":"ProteinBERT2-35M"}. This record does not assert independent reproduction. ### JEPA-only ROC-AUC: 0.762. Result ID: 6a01a66247f34ce924e3f7dd. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-150M"}. This record does not assert independent reproduction. ### All-pos MLM+JEPA ROC-AUC: 0.734. Result ID: 6a01a66247f34ce924e3f7e9. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"Rand-Init-35M"}. This record does not assert independent reproduction. ### JEPA-only ROC-AUC: 0.702. Result ID: 6a01a66247f34ce924e3f7e8. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"Rand-Init-35M"}. This record does not assert independent reproduction. ### JEPA-only ROC-AUC: 0.696. Result ID: 6a01a66247f34ce924e3f7e3. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"AMPLIFY-120M"}. This record does not assert independent reproduction. ### JEPA-only ROC-AUC: 0.643. Result ID: 6a01a66247f34ce924e3f7d7. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ESM2-35M"}. This record does not assert independent reproduction. ### JEPA-only ROC-AUC: 0.638. Result ID: 6a01a66247f34ce924e3f7ed. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Backbone":"ProteinBERT2-35M"}. This record does not assert independent reproduction. Page 1 of 1. This is an index page, not the full collection.